{"title":"N- 未取代的 2- 和 3-呋喃胺的合成与表征。","authors":"Amavi Kpoezoun, Houda Gazzeh, Gnon Baba, Jean-Claude Guillemin","doi":"10.1021/acs.joc.4c00914","DOIUrl":null,"url":null,"abstract":"<p><p>N-unsubstituted 2-furanmethanimine and 3-furanmethanimine are the simplest derivatives of an imine family containing numerous drugs. They have been prepared in the gas phase by dehydrocyanation of the corresponding α-aminonitriles, characterized by IR and NMR spectroscopy at low temperature and used in transimination reactions. The kinetic stability of the furanaldimines lies between that of alkylated and arylated derivatives, demonstrating the role played by the substituent. The triethylborane complexes of the aldimines were synthesized by reacting the corresponding nitriles with superhydride.</p>","PeriodicalId":57,"journal":{"name":"The Journal of Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and Characterization of N-Unsubstituted 2- and 3-Furanimines.\",\"authors\":\"Amavi Kpoezoun, Houda Gazzeh, Gnon Baba, Jean-Claude Guillemin\",\"doi\":\"10.1021/acs.joc.4c00914\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>N-unsubstituted 2-furanmethanimine and 3-furanmethanimine are the simplest derivatives of an imine family containing numerous drugs. They have been prepared in the gas phase by dehydrocyanation of the corresponding α-aminonitriles, characterized by IR and NMR spectroscopy at low temperature and used in transimination reactions. The kinetic stability of the furanaldimines lies between that of alkylated and arylated derivatives, demonstrating the role played by the substituent. The triethylborane complexes of the aldimines were synthesized by reacting the corresponding nitriles with superhydride.</p>\",\"PeriodicalId\":57,\"journal\":{\"name\":\"The Journal of Organic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Organic Chemistry\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.joc.4c00914\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Organic Chemistry","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1021/acs.joc.4c00914","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/11 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Synthesis and Characterization of N-Unsubstituted 2- and 3-Furanimines.
N-unsubstituted 2-furanmethanimine and 3-furanmethanimine are the simplest derivatives of an imine family containing numerous drugs. They have been prepared in the gas phase by dehydrocyanation of the corresponding α-aminonitriles, characterized by IR and NMR spectroscopy at low temperature and used in transimination reactions. The kinetic stability of the furanaldimines lies between that of alkylated and arylated derivatives, demonstrating the role played by the substituent. The triethylborane complexes of the aldimines were synthesized by reacting the corresponding nitriles with superhydride.
期刊介绍:
The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.