{"title":"纳米胶囊化溴氰菊酯与茚虫威的结合:防治蚜虫的有效协同作用","authors":"Marine Galloux, Guillaume Bastiat, Corinne Lefrancois, Véronique Apaire-Marchais, Caroline Deshayes","doi":"10.1584/jpestics.d24-003","DOIUrl":null,"url":null,"abstract":"</p><p>Widespread pesticide use for decades has caused environmental damage, biodiversity loss, serious human and animal health problems, and resistance to insecticides. Innovative strategies are needed to reduce treatment doses in pest management and to overcome insecticide resistance. In the present study, combinations of indoxacarb, an oxadiazine insecticide, with sublethal concentrations of deltamethrin encapsulated in lipid nanocapsules, have been tested on the crop pest <i>Acyrthosiphon pisum</i>. <i>In vivo</i> toxicological tests on <i>A. pisum</i> larvae have shown a synergistic effect of nanoencapsulated deltamethrin with a low dose of indoxacarb. Furthermore, the stability of deltamethrin nanoparticles has been demonstrated <i>in vitro</i> under different mimicking environmental conditions. In parallel, the integrity and stability of lipid nanoparticles in the digestive system of aphid larvae over time have been observed by Förster Resonance Energy Transfer (FRET) imaging. Thus, the deltamethrin nanocapsules/indoxacarb synergistic association is promising for the development of future formulations against pest insects to reduce insecticide doses.</p>\n<p></p>\n<img alt=\"\" src=\"https://www.jstage.jst.go.jp/pub/jpestics/advpub/0/advpub_D24-003/figure/advpub_D24-003.png\"/>\n<span style=\"padding-left:5px;\">Fullsize Image</span>","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"59 1","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nanoencapsulated deltamethrin combined with indoxacarb: An effective synergistic association against aphids\",\"authors\":\"Marine Galloux, Guillaume Bastiat, Corinne Lefrancois, Véronique Apaire-Marchais, Caroline Deshayes\",\"doi\":\"10.1584/jpestics.d24-003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"</p><p>Widespread pesticide use for decades has caused environmental damage, biodiversity loss, serious human and animal health problems, and resistance to insecticides. Innovative strategies are needed to reduce treatment doses in pest management and to overcome insecticide resistance. In the present study, combinations of indoxacarb, an oxadiazine insecticide, with sublethal concentrations of deltamethrin encapsulated in lipid nanocapsules, have been tested on the crop pest <i>Acyrthosiphon pisum</i>. <i>In vivo</i> toxicological tests on <i>A. pisum</i> larvae have shown a synergistic effect of nanoencapsulated deltamethrin with a low dose of indoxacarb. Furthermore, the stability of deltamethrin nanoparticles has been demonstrated <i>in vitro</i> under different mimicking environmental conditions. In parallel, the integrity and stability of lipid nanoparticles in the digestive system of aphid larvae over time have been observed by Förster Resonance Energy Transfer (FRET) imaging. Thus, the deltamethrin nanocapsules/indoxacarb synergistic association is promising for the development of future formulations against pest insects to reduce insecticide doses.</p>\\n<p></p>\\n<img alt=\\\"\\\" src=\\\"https://www.jstage.jst.go.jp/pub/jpestics/advpub/0/advpub_D24-003/figure/advpub_D24-003.png\\\"/>\\n<span style=\\\"padding-left:5px;\\\">Fullsize Image</span>\",\"PeriodicalId\":16712,\"journal\":{\"name\":\"Journal of Pesticide Science\",\"volume\":\"59 1\",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pesticide Science\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1584/jpestics.d24-003\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENTOMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pesticide Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1584/jpestics.d24-003","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENTOMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
几十年来,杀虫剂的广泛使用造成了环境破坏、生物多样性丧失、严重的人类和动物健康问题以及对杀虫剂的抗药性。我们需要创新的策略来减少害虫管理中的处理剂量,并克服杀虫剂的抗药性。在本研究中,茚虫威(一种噁二嗪类杀虫剂)与封装在脂质纳米胶囊中的亚致死浓度溴氰菊酯的组合物在农作物害虫 Acyrthosiphon pisum 上进行了试验。对 A. pisum 幼虫进行的体内毒理学测试表明,纳米封装的溴氰菊酯与低剂量的茚虫威具有协同作用。此外,在不同的模拟环境条件下,体外实验也证明了溴氰菊酯纳米颗粒的稳定性。同时,还通过佛斯特共振能量转移(FRET)成像技术观察了脂质纳米粒子在蚜虫幼虫消化系统中的完整性和稳定性。因此,溴氰菊酯纳米胶囊与茚虫威的协同作用有望用于未来害虫制剂的开发,以减少杀虫剂剂量。
Nanoencapsulated deltamethrin combined with indoxacarb: An effective synergistic association against aphids
Widespread pesticide use for decades has caused environmental damage, biodiversity loss, serious human and animal health problems, and resistance to insecticides. Innovative strategies are needed to reduce treatment doses in pest management and to overcome insecticide resistance. In the present study, combinations of indoxacarb, an oxadiazine insecticide, with sublethal concentrations of deltamethrin encapsulated in lipid nanocapsules, have been tested on the crop pest Acyrthosiphon pisum. In vivo toxicological tests on A. pisum larvae have shown a synergistic effect of nanoencapsulated deltamethrin with a low dose of indoxacarb. Furthermore, the stability of deltamethrin nanoparticles has been demonstrated in vitro under different mimicking environmental conditions. In parallel, the integrity and stability of lipid nanoparticles in the digestive system of aphid larvae over time have been observed by Förster Resonance Energy Transfer (FRET) imaging. Thus, the deltamethrin nanocapsules/indoxacarb synergistic association is promising for the development of future formulations against pest insects to reduce insecticide doses.
期刊介绍:
The Journal of Pesticide Science publishes the results of original research regarding the chemistry and biochemistry of pesticides including bio-based materials. It also covers their metabolism, toxicology, environmental fate and formulation.