用于临床检测的工程纳米颗粒

IF 37.6
Jiyong Cheong, Ala Jo, Jangwon Lee, Sujin Lee, Jung-uk Lee, Jae-Hyun Lee, Hakho Lee, Jinwoo Cheon
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引用次数: 0

摘要

纳米粒子具有独特的物理和化学特性,使其成为光学、磁学或电信号传导的有效媒介。因此,纳米粒子越来越多地被用于开发可快速准确检测疾病的生物传感系统,其潜在应用范围已扩展到护理点设置。在本综述中,我们将讨论将纳米粒子转化为临床诊断的关键环节,包括粒子优化、设备构建和生物传感应用。我们将重点讨论两种具有代表性的粒子类型:金纳米粒子和磁性铁氧体纳米粒子,这两种粒子在生物传感领域得到了广泛应用。我们解释了这些粒子的特性,并说明了如何定制它们以检测核酸、蛋白质和小分子等各种分析目标。最后,我们讨论了推进纳米粒子检测临床整合的新兴研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Engineered nanoparticles for clinical assays

Engineered nanoparticles for clinical assays

Engineered nanoparticles for clinical assays
Nanoparticles exhibit distinctive physical and chemical properties that make them effective mediators for optical, magnetic or electric signal transduction. Consequently, nanoparticles are increasingly used in the development of biosensing systems that can detect diseases rapidly and accurately, with potential applications extending to point-of-care settings. In this Review, we discuss key aspects of translating nanoparticles into clinical diagnostics, including particle optimization, device construction and biosensing applications. We focus on two representative particle types; gold nanoparticles and magnetic ferrite nanoparticles, which are widely used in biosensing. We explain the characteristics of these particles and illustrate how they can be tailored to detect various analytical targets such as nucleic acids, proteins and small molecules. Finally, we discuss emerging research directions to advance the clinical integration of nanoparticle assays. Nanoparticles, such as gold nanoparticles and magnetic ferrite nanoparticles, can be applied in biosensors for disease detection. This Review discusses the design of nanoparticles for clinical diagnostics, focusing on their optimization and device construction for the detection of nucleic acids, proteins and small molecules.
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