嗪草酰胺 A 和 B 的全合成及抗菌评价

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2024-07-02 DOI:10.1016/j.tetlet.2024.155177

Yuto Katayama , Yudai Nishikawa , Minoru Inagaki , Jiyoon Park , Dong-Chan Oh , Yuichi Masuda

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引用次数: 0

摘要

本文报告了抗菌环六肽 nicrophorusamides A（）和 B（）的全合成过程，这两个肽是从属于......属的放线菌菌株 UTG9 中分离出来的。合成过程包括固相肽延伸和溶液相大内酰胺化，然后去除保护基团。通过肉汤微稀释法测定，合成的肽对放线菌菌株 UTG9 的生长具有抑制作用，最低抑制浓度（MIC）分别为 8 μg/mL 和 16 μg/mL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Total synthesis and antibacterial evaluation of nicrophorusamides A and B

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Total synthesis and antibacterial evaluation of nicrophorusamides A and B

This paper reports the total synthesis of antibacterial cyclic hexapeptides nicrophorusamides A (1) and B (2), isolated from the actinomycete strain UTG9 belonging to the genus Microbacterium. The synthesis involved solid-phase peptide elongation and solution-phase macrolactamization, followed by the removal of the protecting groups. Synthetic 1 and 2 demonstrated inhibitory effects on the growth of S. aureus, with minimum inhibitory concentration (MIC) values of 8 μg/mL and 16 μg/mL, respectively, determined using the broth microdilution method.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.