Jing-Bo Li, Jing Jiang, Lian Xue, Shuai Zhao, Hong-Quan Liu
{"title":"白金丸治疗伴有认知障碍的全身强直-阵挛发作性癫痫的临床疗效。","authors":"Jing-Bo Li, Jing Jiang, Lian Xue, Shuai Zhao, Hong-Quan Liu","doi":"10.5498/wjp.v14.i6.938","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The generalized tonic-clonic seizure (GTCS) is the most usual variety of epileptic seizure. It is mainly characterized by strong body muscle rigidity, loss of consciousness, a disorder of plant neurofunction, and significant damage to cognitive function. The effect of antiepileptic drugs on cognition should also be considered. At present, there is no effective treatment for patients with epilepsy, but traditional Chinese medicine has shown a significant effect on chronic disease with fewer harmful side effects and should, therefore, be considered for the therapy means of epilepsy with cognitive dysfunction.</p><p><strong>Aim: </strong>To investigate the clinical efficacy of Baijin pills for treating GTCS patients with cognitive impairment.</p><p><strong>Methods: </strong>This prospective study enrolled patients diagnosed with GTCS between January 2020 and December 2023 and separate them into two groups (experimental and control) using random number table method. The control group was treated with sodium valproate, and the experimental group was Baijin pills and sodium valproate for three months. The frequency and duration of each seizure, the Montreal Cognitive Assessment Scale (MoCA), and the Quality of Life Rating Scale (QOLIE-31) were recorded before and after treatment.</p><p><strong>Results: </strong>There were 85 patients included (42 in the control group and 43 in the experimental group). After treatment, the seizure frequency in the experimental group was significantly reduced (<i>P</i> < 0.05), and seizure duration was shortened (<i>P</i> < 0.01). The total MoCA score in the experimental group significantly increased compared to before treatment (<i>P</i> < 0.01), and the sub-item scores, except naming and abstract generalization ability, significantly increased (<i>P</i> < 0.05), whereas the total MoCA score in the control group significantly decreased after treatment (<i>P</i> < 0.05). The QOLIE-31 score of the experimental group increased significantly after treatment compared to before treatment (<i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Baijin pills have a good clinical effect on epilepsy with cognitive dysfunction.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11230082/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical efficacy of Baijin pills in the treatment of generalized tonic-clonic seizure epilepsy with cognitive impairment.\",\"authors\":\"Jing-Bo Li, Jing Jiang, Lian Xue, Shuai Zhao, Hong-Quan Liu\",\"doi\":\"10.5498/wjp.v14.i6.938\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The generalized tonic-clonic seizure (GTCS) is the most usual variety of epileptic seizure. It is mainly characterized by strong body muscle rigidity, loss of consciousness, a disorder of plant neurofunction, and significant damage to cognitive function. The effect of antiepileptic drugs on cognition should also be considered. At present, there is no effective treatment for patients with epilepsy, but traditional Chinese medicine has shown a significant effect on chronic disease with fewer harmful side effects and should, therefore, be considered for the therapy means of epilepsy with cognitive dysfunction.</p><p><strong>Aim: </strong>To investigate the clinical efficacy of Baijin pills for treating GTCS patients with cognitive impairment.</p><p><strong>Methods: </strong>This prospective study enrolled patients diagnosed with GTCS between January 2020 and December 2023 and separate them into two groups (experimental and control) using random number table method. The control group was treated with sodium valproate, and the experimental group was Baijin pills and sodium valproate for three months. The frequency and duration of each seizure, the Montreal Cognitive Assessment Scale (MoCA), and the Quality of Life Rating Scale (QOLIE-31) were recorded before and after treatment.</p><p><strong>Results: </strong>There were 85 patients included (42 in the control group and 43 in the experimental group). After treatment, the seizure frequency in the experimental group was significantly reduced (<i>P</i> < 0.05), and seizure duration was shortened (<i>P</i> < 0.01). The total MoCA score in the experimental group significantly increased compared to before treatment (<i>P</i> < 0.01), and the sub-item scores, except naming and abstract generalization ability, significantly increased (<i>P</i> < 0.05), whereas the total MoCA score in the control group significantly decreased after treatment (<i>P</i> < 0.05). The QOLIE-31 score of the experimental group increased significantly after treatment compared to before treatment (<i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Baijin pills have a good clinical effect on epilepsy with cognitive dysfunction.</p>\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-06-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11230082/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5498/wjp.v14.i6.938\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5498/wjp.v14.i6.938","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
Clinical efficacy of Baijin pills in the treatment of generalized tonic-clonic seizure epilepsy with cognitive impairment.
Background: The generalized tonic-clonic seizure (GTCS) is the most usual variety of epileptic seizure. It is mainly characterized by strong body muscle rigidity, loss of consciousness, a disorder of plant neurofunction, and significant damage to cognitive function. The effect of antiepileptic drugs on cognition should also be considered. At present, there is no effective treatment for patients with epilepsy, but traditional Chinese medicine has shown a significant effect on chronic disease with fewer harmful side effects and should, therefore, be considered for the therapy means of epilepsy with cognitive dysfunction.
Aim: To investigate the clinical efficacy of Baijin pills for treating GTCS patients with cognitive impairment.
Methods: This prospective study enrolled patients diagnosed with GTCS between January 2020 and December 2023 and separate them into two groups (experimental and control) using random number table method. The control group was treated with sodium valproate, and the experimental group was Baijin pills and sodium valproate for three months. The frequency and duration of each seizure, the Montreal Cognitive Assessment Scale (MoCA), and the Quality of Life Rating Scale (QOLIE-31) were recorded before and after treatment.
Results: There were 85 patients included (42 in the control group and 43 in the experimental group). After treatment, the seizure frequency in the experimental group was significantly reduced (P < 0.05), and seizure duration was shortened (P < 0.01). The total MoCA score in the experimental group significantly increased compared to before treatment (P < 0.01), and the sub-item scores, except naming and abstract generalization ability, significantly increased (P < 0.05), whereas the total MoCA score in the control group significantly decreased after treatment (P < 0.05). The QOLIE-31 score of the experimental group increased significantly after treatment compared to before treatment (P < 0.01).
Conclusion: Baijin pills have a good clinical effect on epilepsy with cognitive dysfunction.
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