AZFc微缺失患者的极重度少精子症可能会影响卵胞浆内单精子注射的临床结果：倾向得分匹配分析

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2024-07-09 eCollection Date: 2024-01-01 DOI:10.1002/rmb2.12596

Huan Zhang, Huanzhu Li, Shujuan Ma, Shuoping Zhang, Wen Li, Yifan Gu, Erchen Zhang, Liang Hu

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引用次数: 0

摘要

目的：探讨AZFc微缺失患者的精子是否会影响卵胞浆内单精子注射（ICSI）的结果：方法：招募 85 名 AZFc 小缺失患者。方法：招募 85 名 AZFc 微缺失患者，采用倾向得分匹配分析法，以 1:2 的近邻算法比例筛选出 140 名无 AZF 微缺失的重度少精症患者作为对照组。比较了两组患者的 ICSI 结果：结果：AZFc微缺失组的正常受精率（73% vs. 80%，p = 0.17）和优质胚胎率（44% vs. 58%，p = 0.07）均低于对照组。两组的临床妊娠率、流产率和活产率无明显差异。当精子浓度为 p = 0.03 时，优质胚胎率（44% 对 58%，p = 0.02）、临床妊娠率（57% 对 76%，p = 0.02）和活产率（49% 对 72%，p = 0.01）均高于对照组。然而，如果精子浓度≥100 万/毫升，则没有发现显著差异：结论：如果精子浓度为

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Very severe oligozoospermia with AZFc microdeletion patients may affect intracytoplasmic sperm injection clinical outcomes: A propensity score matching analysis.

Purpose: To explore whether spermatozoa from AZFc microdeletion patients affect their outcomes of intracytoplasmic sperm injection (ICSI).

Methods: Eighty-five patients with AZFc microdeletion were recruited. A control group of one hundred and forty patients with severe oligozoospermia but without AZF microdeletion was selected using propensity score matching analysis with a 1:2 nearest neighbor algorithm ratio. The ICSI outcomes of the two groups were compared.

Results: AZFc microdeletion had lower rates of normal fertilization (73% vs. 80%, p = 0.17) and high-quality embryos (44% vs. 58%, p = 0.07) than the control group. There was no significant difference in the clinical pregnancy rate, miscarriage rate, and live birth rate between the two groups. When the sperm concentration was <1 million/mL, the AZFc microdeletion group exhibited lower rates of fertilization (71% vs. 80%, p = 0.03), high-quality embryo (44% vs. 58%, p = 0.02), clinical pregnancy (57% vs. 76%, p = 0.02), and live birth (49% vs. 72%, p = 0.01) than the control group. However, if sperm concentration was ≥1 million/mL, no significant differences were found.

Conclusion: If the sperm concentration is <1 million/mL, AZFc microdeletion do have a detrimental effect on most outcomes of ICSI.

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.