作为大鼠神经性疼痛生物标志物的脑血流动力学:使用脊神经结扎模型的纵向研究。

IF 5.9 1区 医学 Q1 ANESTHESIOLOGY
PAIN® Pub Date : 2025-01-01 Epub Date: 2024-07-10 DOI:10.1097/j.pain.0000000000003332
Seokha Jin, Hyung Joon Cho
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引用次数: 0

摘要

摘要:神经性疼痛是诊断和治疗最具挑战性的疼痛类型之一,由于缺乏定量生物标志物,这一问题变得更加严重。最近,一些临床和临床前研究表明,神经病理性疼痛会诱发脑血流动力学变化,这是大脑神经可塑性的结果。本研究的假设是,在脊神经结扎(SNL)大鼠模型中,神经病理性疼痛会导致脑血流动力学随术后时间的变化而变化,而这在以前还没有进行过纵向探索。此外,通过识别 SNL 组和假组之间最明显的多个区域血流动力学特征(假组只进行了切口而没有进行 SNL),或许可以对 SNL 组进行分类,而不管疼痛何时发生。我们利用动态感性对比磁共振成像技术研究了大鼠模型在结扎 L5/L6 脊髓神经后 28 天内的脑血流动力学变化。我们利用来自不同脑区的相对脑血量数据训练了一个线性支持向量机,结果发现,无论疼痛何时发生(SNL/sham:60/45 个数据点),针对伏隔核、运动皮层、前直觉区和丘脑训练的预测模型都能以 79.27% 的均衡准确率对 SNL 组和假组进行分类。在不预先知道疼痛发作时间的情况下使用SNL模型,目前的研究结果凸显了4个突出脑区的相对脑血量作为神经病理性疼痛生物标志物的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cerebral hemodynamics as biomarkers for neuropathic pain in rats: a longitudinal study using a spinal nerve ligation model.

Abstract: Neuropathic pain is one of the most challenging types of pain to diagnose and treat, a problem exacerbated by the lack of a quantitative biomarker. Recently, several clinical and preclinical studies have shown that neuropathic pain induces cerebral hemodynamic changes as a result of neuroplasticity in the brain. Our hypothesis in this study is that neuropathic pain leads to cerebral hemodynamic changes over postoperative time in a spinal nerve ligation (SNL) rat model, which has not been longitudinally explored previously. Furthermore, by identifying multiple regional hemodynamic features that are the most distinct between SNL and sham groups, where the sham group underwent only an incision without SNL, it may be possible to classify the SNL group regardless of when the onset of pain occurs. We investigate cerebral hemodynamic changes using dynamic susceptibility contrast magnetic resonance imaging in a rat model up to 28 days after ligating L5/L6 spinal nerves. We trained a linear support vector machine with relative cerebral blood volume data from different brain regions and found that the prediction model trained on the nucleus accumbens, motor cortex, pretectal area, and thalamus classified the SNL group and sham group at a 79.27% balanced accuracy, regardless of when the onset of pain occurred (SNL/sham: 60/45 data points). From the use of the SNL model without prior knowledge of the onset time of pain, the current findings highlight the potential of relative cerebral blood volume in the 4 highlighted brain regions as a biomarker for neuropathic pain.

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来源期刊
PAIN®
PAIN® 医学-临床神经学
CiteScore
12.50
自引率
8.10%
发文量
242
审稿时长
9 months
期刊介绍: PAIN® is the official publication of the International Association for the Study of Pain and publishes original research on the nature,mechanisms and treatment of pain.PAIN® provides a forum for the dissemination of research in the basic and clinical sciences of multidisciplinary interest.
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