P Wändell, M A Enarsson, T Feldreich, L Lind, J Ärnlöv, A C Carlsson
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Cox regression analysis with hazard ratios (HRs) using updated covariates for PA and risk factors was performed on the association of PA levels with incident VTE, with adjustments for established cardiovascular risk factors (systolic blood pressure, LDL- and HDL-cholesterol, BMI, diabetes, and smoking). Totally 186 men experienced a VTE during follow-up of 68,263 person-years at risk. Individuals with the highest PA level had an increased relative risk of VTE, adjusted HR, 2.22 (95% CI 1.05-4.67), when compared to individuals with the lowest level of PA. In this cohort of men with a follow-up of 27 years, the risk of VTE was increased at the highest PA level. 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引用次数: 0
摘要
静脉血栓栓塞症(VTE)是第三大常见心血管疾病。以往的一些研究发现,高水平的体力活动(PA)与 VTE 的发病有关联,但并非所有研究都发现了这一点。我们的目的是在一个男性队列中研究 PA 水平与 VTE 之间的关系,该队列拥有四次更新的 PA 水平数据。我们使用了 1970 年启动的乌普萨拉成年男性纵向研究(ULSAM)的数据,该研究通过问卷调查和传统心血管风险因素对 50 岁男性(基线人数为 2294 人)的闲暇时间 PA 进行了调查。在 60 岁、70 岁和 77 岁时进行了重复检查,中位随访时间为 33 年。在对已确定的心血管风险因素(收缩压、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇、体重指数、糖尿病和吸烟)进行调整后,使用最新的休闲活动和风险因素协变量对休闲活动水平与发生 VTE 的关系进行了危险比 (HR) 的 Cox 回归分析。在68,263人年的风险随访期间,共有186名男性发生了VTE。与 PA 水平最低的人相比,PA 水平最高的人发生 VTE 的相对风险增加,调整后 HR 为 2.22(95% CI 1.05-4.67)。在这组随访了 27 年的男性人群中,PA 水平越高,发生 VTE 的风险越高。研究结果表明,包括剧烈活动在内的较高PA水平可能会增加VTE风险。
Risk of venous thromboembolism in relation to high physical activity level in men over 27 year follow up.
Venous thromboembolism (VTE) is the third most common type of cardiovascular disease. An association between high level of physical activity (PA) and the onset of VTE has been found in some, but not all previous studies. We aim to study the association between PA-level and VTE in a cohort of men with updated data on PA levels at four occasions. We used data from the Uppsala Longitudinal Study of Adult Men (ULSAM) study initiated in 1970, a study of men at age 50 years (n = 2,294 at baseline) examined on leisure time PA by questionnaire and traditional cardiovascular risk factors. Examinations were repeated at ages 60, 70, and 77, and follow-up was completed after a median time of 33 years. Cox regression analysis with hazard ratios (HRs) using updated covariates for PA and risk factors was performed on the association of PA levels with incident VTE, with adjustments for established cardiovascular risk factors (systolic blood pressure, LDL- and HDL-cholesterol, BMI, diabetes, and smoking). Totally 186 men experienced a VTE during follow-up of 68,263 person-years at risk. Individuals with the highest PA level had an increased relative risk of VTE, adjusted HR, 2.22 (95% CI 1.05-4.67), when compared to individuals with the lowest level of PA. In this cohort of men with a follow-up of 27 years, the risk of VTE was increased at the highest PA level. Findings indicate that there could be an increased VTE risk with higher PA level including strenuous activities.
期刊介绍:
The Journal of Thrombosis and Thrombolysis is a long-awaited resource for contemporary cardiologists, hematologists, vascular medicine specialists and clinician-scientists actively involved in treatment decisions and clinical investigation of thrombotic disorders involving the cardiovascular and cerebrovascular systems. The principal focus of the Journal centers on the pathobiology of thrombosis and vascular disorders and the use of anticoagulants, platelet antagonists, cell-based therapies and interventions in scientific investigation, clinical-translational research and patient care.
The Journal will publish original work which emphasizes the interface between fundamental scientific principles and clinical investigation, stimulating an interdisciplinary and scholarly dialogue in thrombosis and vascular science. Published works will also define platforms for translational research, drug development, clinical trials and patient-directed applications. The Journal of Thrombosis and Thrombolysis'' integrated format will expand the reader''s knowledge base and provide important insights for both the investigation and direct clinical application of the most rapidly growing fields in medicine-thrombosis and vascular science.