氧化平衡评分与痛风风险之间的关系：2007-2018年NHANES横断面研究。

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases Pub Date : 2024-07-10 DOI:10.1111/1756-185X.15255

Fanzhang Meng, Siyi Lu, Yingzi Li, Chen Zhang, Tianlun Kang, Tangliang Qian, Chao Tan, Xiaoping Liu, Xiujuan Hou

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引用次数: 0

摘要

背景：氧化平衡评分（OBS）是一种系统工具，用于评估饮食和生活方式对氧化应激的影响。此前尚未有关于 OBS 与痛风之间关系的报道。我们进行了一项横断面研究，以调查美国成年人的 OBS 与痛风之间的复杂关联：本研究共纳入了 10 492 名参与者。暴露变量为OBS，由16个饮食因素和4个生活方式因素评分。采用多变量逻辑回归、亚组分析和限制性立方样条（RCS）回归分析OBS与痛风之间的关系：与OBS最低四分位组（Q1）相比，OBS最高四分位组（Q4）的多变量校正比值比（OR）（95%置信区间[C]）为0.72（0.52-1.00）（p = .13为趋势）；此外，RCS显示OBS与痛风之间存在负线性关系（p-nonlinear = .606）：结论：总之，OBS 高的人患痛风的风险更高。结论：OBS 越高，痛风的患病率越低。糖尿病可能会改变这种负相关关系。

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Association between oxidative balance score and risk of gout: The NHANES cross-sectional study, 2007–2018

Background

The Oxidative Balance Score (OBS) is a systematic tool to assess the effects of diet and lifestyle in relation to oxidative stress. The association between OBS and gout has not been reported previously. We conducted a cross-sectional study to investigate the complex association between OBS and gout in US adults.

Methods

In all, 10 492 participants were included in this study. The exposure variable was OBS, which was scored by 16 dietary and four lifestyle factors. Multivariate logistic regression, subgroup analysis, and restricted cubic spline (RCS) regression were used to analyze the association between OBS and gout.

Results

Compared with the lowest OBS quartile group (Q1), the multivariate corrected odds ratio (OR) (95% confidence interval [C]) for the highest quartile of OBS (Q4) was 0.72 (0.52–1.00) (p = .13 for trend); furthermore, the RCS showed a negative linear relationship between OBS and gout (p-nonlinear = .606).

Conclusion

In conclusion, the risk of gout is higher with high OBS. The prevalence of gout decreased with higher OBS. Diabetes may alter this negative correlation.

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来源期刊

International Journal of Rheumatic Diseases RHEUMATOLOGY-

CiteScore

3.70

自引率

4.00%

发文量

362

审稿时长

1 months

期刊介绍： The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.