Juan Fu, Lin Mao, Yu Jiao, Desheng Mei, Yadong Chen
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引用次数: 0
摘要
细胞毒性T淋巴细胞相关抗原4（CTLA-4）是一种关键的单链跨膜糖蛋白，主要在效应T细胞和调节性T细胞中表达。它通过调节 T 细胞反应在肿瘤免疫中发挥关键作用。具体来说，CTLA-4 通过与 B7 家族分子的竞争性相互作用，抑制 T 细胞的活化和增殖，同时提高调节性 T 细胞的存活率，从而帮助肿瘤细胞躲避免疫检测。鉴于 CTLA-4 对肿瘤免疫动态的重大影响，临床上已开发出一系列抗 CTLA-4 抗体疗法，用于抗击各种恶性肿瘤，包括黑色素瘤、肾细胞癌、结直肠癌、肝细胞癌、非小细胞肺癌和胸膜间皮瘤，并显示出显著的临床治疗效果。本文旨在深入探讨 CTLA-4 在肿瘤免疫中的重要作用，并总结抗 CTLA-4 抗体临床研究的最新进展。
Elucidating CTLA-4's role in tumor immunity: a comprehensive overview of targeted antibody therapies and clinical developments.
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) emerges as a key single-chain transmembrane glycoprotein predominantly expressed in effector T cells and regulatory T cells. It plays a crucial role in tumor immunity by modulating T cell responses. Specifically, CTLA-4 dampens T cell activation and proliferation while bolstering the survival of regulatory T cell through its competitive interaction with B7 family molecules, thereby aiding tumor cells in eluding immune detection. Given CTLA-4's significant influence on tumor immune dynamics, an array of anti-CTLA-4 antibody therapeutics have been clinically developed to combat various malignancies, including melanoma, renal cell carcinoma, colorectal carcinoma, hepatocellular carcinoma, non-small cell lung carcinoma, and pleural mesothelioma, demonstrating notable clinical therapeutic effects. This paper aims to delve into CTLA-4's integral role in tumor immunity and to encapsulate the latest advancements in the clinical research of anti-CTLA-4 antibody.
期刊介绍：
Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including:
combinatorial chemistry and parallel synthesis;
small molecule libraries;
microwave synthesis;
flow synthesis;
fluorous synthesis;
diversity oriented synthesis (DOS);
nanoreactors;
click chemistry;
multiplex technologies;
fragment- and ligand-based design;
structure/function/SAR;
computational chemistry and molecular design;
chemoinformatics;
screening techniques and screening interfaces;
analytical and purification methods;
robotics, automation and miniaturization;
targeted libraries;
display libraries;
peptides and peptoids;
proteins;
oligonucleotides;
carbohydrates;
natural diversity;
new methods of library formulation and deconvolution;
directed evolution, origin of life and recombination;
search techniques, landscapes, random chemistry and more;
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