Jae-Hwan Lee, Jae-Young Bae, Yoon-Nam Kim, Minseong Chae, Woo-Jin Lee, Junsang Lee, Im-Deok Kim, Jung Keun Hyun, Kang-Sik Lee, Daeshik Kang, Seung-Kyun Kang
{"title":"用于生物力学信号监测的全生物降解超灵敏裂缝应变传感器","authors":"Jae-Hwan Lee, Jae-Young Bae, Yoon-Nam Kim, Minseong Chae, Woo-Jin Lee, Junsang Lee, Im-Deok Kim, Jung Keun Hyun, Kang-Sik Lee, Daeshik Kang, Seung-Kyun Kang","doi":"10.1002/adfm.202406035","DOIUrl":null,"url":null,"abstract":"A fully biodegradable, ultra-sensitive, and soft strain sensor is pivotal for temporary, real-time monitoring of microdeformations, crucial in disease diagnosis, surgical precision, and prognosis of muscular, and vascular conditions. Nevertheless, the strain sensitivity of previous biodegradable sensors, denoted by gauge factor (GF) up to ≈100, falls short of requirements for complex biomedical monitoring scenarios, specifically monitoring cardio-cerebrovascular diseases with microscale variations in vascular surface strain. Here, a fully biodegradable, ultra-sensitive crack-based flexible strain sensor is introduced achieving GF of 1355 at 1.5% strain through integration of molybdenum (Mo) film, molybdenum trioxide (MoO<sub>3</sub>) adhesion layer, and polycaprolactone (PCL) substrate. Analysis of crack morphology of biodegradable thin-film metals, including Mo, tungsten (W), and magnesium (Mg), reveals material-dependent sensitivity and repeatability of crack-based strain sensors. The effect of the adhesion layer and polymer substrate is also investigated. Overall morphological studies on the sensor present a comprehensive understanding of metal film cracking behavior and corresponding performance characterization, showing significant potential for highly sensitive sensors. A hybrid membrane composed of candelilla wax (C<sub>w</sub>), beeswax (B<sub>w</sub>), and polybutylene adipate-co-terephthalate (PBAT) is introduced to provide hydrophobic, yet flexible encapsulation. In vivo, short-term (≈3 days) monitoring of vascular pulsatility underscores the potential of the sensing tool for rapid, accurate, and temporal disease diagnosis and treatment.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":null,"pages":null},"PeriodicalIF":18.5000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Fully Biodegradable and Ultra-Sensitive Crack-Based Strain Sensor for Biomechanical Signal Monitoring\",\"authors\":\"Jae-Hwan Lee, Jae-Young Bae, Yoon-Nam Kim, Minseong Chae, Woo-Jin Lee, Junsang Lee, Im-Deok Kim, Jung Keun Hyun, Kang-Sik Lee, Daeshik Kang, Seung-Kyun Kang\",\"doi\":\"10.1002/adfm.202406035\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A fully biodegradable, ultra-sensitive, and soft strain sensor is pivotal for temporary, real-time monitoring of microdeformations, crucial in disease diagnosis, surgical precision, and prognosis of muscular, and vascular conditions. Nevertheless, the strain sensitivity of previous biodegradable sensors, denoted by gauge factor (GF) up to ≈100, falls short of requirements for complex biomedical monitoring scenarios, specifically monitoring cardio-cerebrovascular diseases with microscale variations in vascular surface strain. Here, a fully biodegradable, ultra-sensitive crack-based flexible strain sensor is introduced achieving GF of 1355 at 1.5% strain through integration of molybdenum (Mo) film, molybdenum trioxide (MoO<sub>3</sub>) adhesion layer, and polycaprolactone (PCL) substrate. Analysis of crack morphology of biodegradable thin-film metals, including Mo, tungsten (W), and magnesium (Mg), reveals material-dependent sensitivity and repeatability of crack-based strain sensors. The effect of the adhesion layer and polymer substrate is also investigated. Overall morphological studies on the sensor present a comprehensive understanding of metal film cracking behavior and corresponding performance characterization, showing significant potential for highly sensitive sensors. A hybrid membrane composed of candelilla wax (C<sub>w</sub>), beeswax (B<sub>w</sub>), and polybutylene adipate-co-terephthalate (PBAT) is introduced to provide hydrophobic, yet flexible encapsulation. In vivo, short-term (≈3 days) monitoring of vascular pulsatility underscores the potential of the sensing tool for rapid, accurate, and temporal disease diagnosis and treatment.\",\"PeriodicalId\":112,\"journal\":{\"name\":\"Advanced Functional Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":18.5000,\"publicationDate\":\"2024-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Functional Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1002/adfm.202406035\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Functional Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1002/adfm.202406035","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
A Fully Biodegradable and Ultra-Sensitive Crack-Based Strain Sensor for Biomechanical Signal Monitoring
A fully biodegradable, ultra-sensitive, and soft strain sensor is pivotal for temporary, real-time monitoring of microdeformations, crucial in disease diagnosis, surgical precision, and prognosis of muscular, and vascular conditions. Nevertheless, the strain sensitivity of previous biodegradable sensors, denoted by gauge factor (GF) up to ≈100, falls short of requirements for complex biomedical monitoring scenarios, specifically monitoring cardio-cerebrovascular diseases with microscale variations in vascular surface strain. Here, a fully biodegradable, ultra-sensitive crack-based flexible strain sensor is introduced achieving GF of 1355 at 1.5% strain through integration of molybdenum (Mo) film, molybdenum trioxide (MoO3) adhesion layer, and polycaprolactone (PCL) substrate. Analysis of crack morphology of biodegradable thin-film metals, including Mo, tungsten (W), and magnesium (Mg), reveals material-dependent sensitivity and repeatability of crack-based strain sensors. The effect of the adhesion layer and polymer substrate is also investigated. Overall morphological studies on the sensor present a comprehensive understanding of metal film cracking behavior and corresponding performance characterization, showing significant potential for highly sensitive sensors. A hybrid membrane composed of candelilla wax (Cw), beeswax (Bw), and polybutylene adipate-co-terephthalate (PBAT) is introduced to provide hydrophobic, yet flexible encapsulation. In vivo, short-term (≈3 days) monitoring of vascular pulsatility underscores the potential of the sensing tool for rapid, accurate, and temporal disease diagnosis and treatment.
期刊介绍:
Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week.
Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.