胰岛中的清道夫助长了糖尿病自身免疫

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-07-09 DOI:10.1016/j.immuni.2024.06.008

Jadie Y. Moon, Katherine A. Gallagher

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引用次数: 0

摘要

浸润胰岛环境并以β细胞为靶细胞的自身反应性淋巴细胞是1型糖尿病的主要诱因。在本期《免疫》杂志上，Srivastava 等人1 研究了胰岛微环境在自身免疫中的作用，发现胰岛驻留巨噬细胞上的清除受体 CXCL16 能吸收氧化的低密度脂蛋白，并促进浸润的致病性 CD8+ T 细胞的分化和存活。

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Scavengers in islets fuel diabetic autoimmunity

Autoreactive lymphocytes that infiltrate the pancreatic islet environment and target β cells are primary drivers of type 1 diabetes. In this issue of Immunity, Srivastava et al.¹ examine the role of the islet microenvironment in autoimmunity and find that the scavenging receptor CXCL16 on islet-resident macrophages uptakes oxidized low-density lipoproteins and promotes the differentiation and survival of infiltrating pathogenic CD8⁺ T cells.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.