IL-18 激活的利弊

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-07-09 DOI:10.1016/j.immuni.2024.06.006

Danielle M. Clancy, Julie Andries, Savvas N. Savvides

引用次数: 0

摘要

白细胞介素-1（IL-1）家族细胞因子是关键的免疫调控因子，它们在经过翻译后蛋白水解加工后才具有信号能力。在本期《免疫》杂志上，Dong 等人揭示了这一过程对原炎性 IL-18 的结构影响，证明原 IL-18 和成熟 IL-18 在结构上是不同的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The pros and confs of IL-18 activation

Interleukin-1 (IL-1) family cytokines are key immunological regulators that achieve their signaling prowess after post-translational proteolytic processing. In this issue of Immunity, Dong et al. reveal the structural consequences of this process on proinflammatory IL-18, demonstrating that pro-IL-18 and mature IL-18 are structurally distinct.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.