{"title":"变色龙冒充 NK 细胞和 ILC1s","authors":"M. Zeeshan Chaudhry, Gabrielle T. Belz","doi":"10.1038/s41590-024-01886-x","DOIUrl":null,"url":null,"abstract":"Innate lymphoid cells (ILCs) exhibit remarkable plasticity, which makes using definitive markers to distinguish non-cytotoxic ILC1s and NK cells across different tissues difficult. New research now shows how the tissue microenvironments imprint diverse phenotypes that result in ILC1s and NK cells imitating each other.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":null,"pages":null},"PeriodicalIF":27.7000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chameleon impersonation of NK cells and ILC1s\",\"authors\":\"M. Zeeshan Chaudhry, Gabrielle T. Belz\",\"doi\":\"10.1038/s41590-024-01886-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Innate lymphoid cells (ILCs) exhibit remarkable plasticity, which makes using definitive markers to distinguish non-cytotoxic ILC1s and NK cells across different tissues difficult. New research now shows how the tissue microenvironments imprint diverse phenotypes that result in ILC1s and NK cells imitating each other.\",\"PeriodicalId\":19032,\"journal\":{\"name\":\"Nature Immunology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":27.7000,\"publicationDate\":\"2024-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41590-024-01886-x\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41590-024-01886-x","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
先天性淋巴细胞(ILCs)具有显著的可塑性,因此很难使用明确的标记物来区分不同组织中的非细胞毒性 ILC1s 和 NK 细胞。现在的新研究显示了组织微环境如何印刻出不同的表型,从而导致ILC1和NK细胞相互模仿。
Innate lymphoid cells (ILCs) exhibit remarkable plasticity, which makes using definitive markers to distinguish non-cytotoxic ILC1s and NK cells across different tissues difficult. New research now shows how the tissue microenvironments imprint diverse phenotypes that result in ILC1s and NK cells imitating each other.
期刊介绍:
Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.