一名胸腺瘤和抗 I 型 IFN 抗体患者的严重西尼罗河病毒和 Sars-CoV-2 感染。

IF 5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2024-07-08 DOI:10.1093/infdis/jiae321

Federica Barzaghi, Camilla Visconti, Giovanni Battista Pipitone, Simone Bondesan, Giulia Molli, Stefania Giannelli, Claudia Sartirana, Vito Lampasona, Elena Bazzigaluppi, Cristina Brigatti, Adrian Gervais, Paul Bastard, Chiara Tassan Din, Chiara Molinari, Lorenzo Piemonti, Jean-Laurent Casanova, Paola Carrera, Giorgio Casari, Alessandro Aiuti

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引用次数: 0

摘要

本研究旨在调查一名曾经历过西尼罗河病毒和 SARS-CoV2 两次危及生命感染的健康患者病情严重程度的决定因素。在 COVID19 住院期间，他被诊断出患有胸腺瘤，经回顾性鉴定，胸腺瘤在感染西尼罗河病毒时就已存在。TLR3 基因中的 p.Pro554Ser 异质性会增加对严重 COVID-19 的易感性，而 CCR5 c.554_585del 同质性会导致严重的 WNV 感染。检测到了中和性抗-IFN-α和抗-IFN-ω自身抗体，这可能是由潜在胸腺瘤诱发的，并增加了对重症COVID-19肺炎和西尼罗河脑炎的易感性。

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Severe West Nile virus and Sars-CoV-2 infections in a patient with thymoma and anti-type I IFN antibodies.

The current study aimed to investigate determinants of severity in a previously healthy patient who experienced two life-threatening infections, from West Nile Virus and SARS-CoV2. During COVID19 hospitalization he was diagnosed with a thymoma, retrospectively identified as already present at the time of WNV infection. Heterozygosity for p.Pro554Ser in the TLR3 gene, which increases susceptibility to severe COVID-19, and homozygosity for CCR5 c.554_585del, associated to severe WNV infection, were found. Neutralizing anti-IFN-α and anti-IFN-ω auto-antibodies were detected, likely induced by the underlying thymoma and increasing susceptibility to both severe COVID-19 pneumonia and West Nile encephalitis.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.