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引用次数: 0
摘要
2006年,人们首次在一些人类前列腺癌中发现了与异型小鼠白血病病毒(MLV)相关的病毒(XMRV)。但直到 2009 年,在肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)患者的样本中也发现了传染性病毒和与 MLV 相关的 DNA,这才引起了人们的注意。这一发现迅速引起了国际研究界的关注,以了解这种关联的重要性及其作为一种重要人类病原体广泛传播的潜力。几年内,全球研究人员的努力都未能重复这些发现,越来越多的证据表明,小鼠源性病毒和病毒 DNA 序列造成了实验室污染,这已被公认为是对最初发现的解释。作为参与这些研究的研究人员,我们在此对 XMRV 作为人类病原体的兴衰进行了历史回顾,并讨论了从这些事件中吸取的教训。
False Alarm: XMRV, Cancer, and Chronic Fatigue Syndrome.
Xenotropic murine leukemia virus (MLV)-related virus (XMRV) was first described in 2006 in some human prostate cancers. But it drew little attention until 2009, when it was also found, as infectious virus and as MLV-related DNA, in samples from people suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This discovery was rapidly followed by efforts of the international research community to understand the significance of the association and its potential to spread widely as an important human pathogen. Within a few years, efforts by researchers worldwide failed to repeat these findings, and mounting evidence for laboratory contamination with mouse-derived virus and viral DNA sequences became accepted as the explanation for the initial findings. As researchers engaged in these studies, we present here a historical review of the rise and fall of XMRV as a human pathogen, and we discuss the lessons learned from these events.
期刊介绍:
The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.