世界卫生组织第五版新分类的阑尾鹅口疮细胞腺癌:病例报告(二次发表)。

IF 0.7 Q4 SURGERY
Takayasu Azuma, Yoshihiro Sato, Hiroto Chiba, Junichiro Haga
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引用次数: 0

摘要

背景:阑尾鹅口疮细胞腺癌(AGCA)是2019年第五版《世界卫生组织肿瘤分类》中新提出的一种癌症类型。我们经历了这种罕见的阑尾原发肿瘤:病例介绍:一名 85 岁的男性大便潜血试验呈阳性。一系列图像检查显示,该患者的阑尾口有一个 1 型肿瘤。随后的活组织检查确诊为印戒细胞癌。因此,他接受了腹腔镜辅助回盲部切除术。起初,该肿瘤被怀疑为鹅口细胞类癌(GCC)。组织学和免疫染色结果之间存在差异:肿瘤细胞的形态与 GCC 相似,但在免疫染色时却显示出有限的染色。最终,我们得出结论,按照世界卫生组织第五版的分类,该肿瘤应归类为 AGCA。AGCA 代表了腺癌的一种新分类亚型。尽管大多数阑尾恶性肿瘤通常是在阑尾切除术后才被发现,但由于术前怀疑是恶性肿瘤,我们还是进行了肿瘤切除术和区域淋巴结清扫术:我们经历的这一病例为理解 AGCA 提供了宝贵的见解,AGCA 是最近在世界卫生组织第五版中确立的病理实体。本文是对Azuma等人的病例报告(J Jpn Surg Assoc 83:1103-1108, 2022)的二次发表,可以接受。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Appendiceal goblet cell adenocarcinoma newly classified by WHO 5th edition: a case report (a secondary publication).

Background: Appendiceal goblet cell adenocarcinoma (AGCA) is a newly proposed cancer type in the 5th edition of the WHO Classification of Tumours in 2019. We experienced this rare form of appendiceal primary neoplasm.

Case presentation: An 85-year-old male presented a positive fecal occult blood test. A series of imagings revealed a type 1 tumor, located on the appendiceal orifice. The subsequent biopsy made the diagnosis of signet-ring cell carcinoma. Consequently, he underwent the laparoscopic-assisted ileocecal resection. Initially, the tumor was suspected to be a Goblet cell carcinoid (GCC). There was a discrepancy between the histological and immunostaining findings: the tumor cells exhibited morphological similarities to GCCs, however displayed limited staining upon immunostaining. Ultimately, we concluded that the tumor should be classified as AGCA, by following WHO 5th Edition. AGCA represents a newly categorized subtype of adenocarcinomas. Because of our preoperative suspicion of malignancy, we performed tumor resection with regional lymph node dissection, despite the fact that most appendiceal malignant tumors are typically identified after an appendectomy.

Conclusion: We experienced a case that provides valuable insights into the comprehension of AGCA, a recently established pathological entity in the WHO 5th Edition. This article is an acceptable secondary publication of a case report that appeared in Azuma et al. (J Jpn Surg Assoc 83:1103-1108, 2022).

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