微型猪脊髓损伤模型的脊髓损伤核磁共振成像和行为结果:通过与人类脊髓损伤的特别比较探索临床前潜力。

IF 0.7 Q4 CLINICAL NEUROLOGY
Andrew C Smith, Rakib Uddin Ahmed, Kenneth A Weber, MohammadJavad Negahdar, Destiny Gibson, Maxwell Boakye, Enrico Rejc
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引用次数: 0

摘要

研究设计:尤卡坦微型猪脊髓挫伤模型的前瞻性病例系列,并与人类脊髓损伤(SCI)病例进行比较。研究目的:描述脊髓损伤严重程度的磁共振成像(MRI)测量值,以及较轻和较重脊髓挫伤 SCI 模型的侧皮质脊髓束幸免神经组织的估计值,并描述其相应的行为结果变化:环境:大学实验室:方法:在较严重和较不严重的脊髓损伤后,每头猪都接受脊髓核磁共振成像以测量病变特征,同时进行运动学和尿动力学结果测试:结果:在脊髓损伤较严重的猪中,运动和尿动力学结果很差,脊髓病变体积和外侧皮质脊髓束的损伤估计值都很大。相反,在损伤程度较轻的猪中,运动和尿动力学结果良好,脊髓损伤体积和外侧皮质脊髓束的损伤估计值较小。对于两个根据外侧皮质脊髓束区域损伤估计值匹配的人类病例,其临床表现与猪的结果相似,其中较严重病例的活动能力更受限制,膀胱功能独立性也更受限制:我们的初步研究结果为基于核磁共振成像评估猪模型脊髓病变这一新兴领域提供了有价值的见解,为了解脊髓损伤并改善其预后提供了一条前景广阔的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Spinal cord lesion MRI and behavioral outcomes in a miniature pig model of spinal cord injury: exploring preclinical potential through an ad hoc comparison with human SCI.

Spinal cord lesion MRI and behavioral outcomes in a miniature pig model of spinal cord injury: exploring preclinical potential through an ad hoc comparison with human SCI.

Study design: prospective case series of Yucatan miniature pig spinal cord contusion injury model with comparison to human cases of spinal cord injury (SCI).

Objectives: to describe magnetic resonance imaging (MRI) measures of spinal cord lesion severity along with estimates of lateral corticospinal tracts spared neural tissue in both a less severe and more severe contusion SCI model, as well as to describe their corresponding behavioral outcome changes.

Setting: University laboratory setting.

Methods: Following a more severe and less severe SCI, each pig underwent spinal cord MRI to measure lesion characteristics, along with locomotor and urodynamics outcomes testing.

Results: In the pig with more severe SCI, locomotor and urodynamic outcomes were poor, and both the spinal cord lesion volume and damage estimates to the lateral corticospinal tracts were large. Conversely, in the pig with less severe SCI, locomotor and urodynamic outcomes were favorable, with the spinal cord lesion volume and damage estimates to the lateral corticospinal tracts being less pronounced. For two human cases matched on estimates of damage to the lateral corticospinal tract regions, the clinical presentations were similar to the pig outcomes, with more limited mobility and more limited bladder functional independence in the more severe case.

Conclusions: Our initial findings contribute valuable insights to the emergent field of MRI-based evaluation of spinal cord lesions in pig models, offering a promising avenue for understanding and potentially improving outcomes in spinal cord injuries.

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来源期刊
Spinal Cord Series and Cases
Spinal Cord Series and Cases Medicine-Neurology (clinical)
CiteScore
2.20
自引率
8.30%
发文量
92
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