投射到椎体末端床核的大脑皮质促肾上腺皮质激素释放激素神经元促进清醒和积极情绪状态

IF 5.9 2区 医学 Q1 NEUROSCIENCES
Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-07-09 DOI:10.1007/s12264-024-01233-y
Gaojie Pan, Bing Zhao, Mutian Zhang, Yanan Guo, Yuhua Yan, Dan Dai, Xiaoxi Zhang, Hui Yang, Jinfei Ni, Zhili Huang, Xia Li, Shumin Duan
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引用次数: 0

摘要

在依赖于高度觉醒的各种情绪和动机行为中,纳氏核(NAc)扮演着重要角色。然而,NAc 中唤醒与情绪调节之间关系的神经机制仍不清楚。在这里,我们研究了 NAc 中抑制性促肾上腺皮质激素释放激素神经元(NAcCRH)的一个特定亚群在调节小鼠唤醒和情绪行为中的作用。我们发现,在觉醒和奖赏刺激过程中,NAcCRH 神经元的活性会增强。激活NAcCRH神经元可将NREM或REM睡眠转化为觉醒,而抑制这些神经元则会减弱觉醒。值得注意的是,激活 NAcCRH 神经元会诱发场所偏好反应(PPR)并降低基础焦虑水平,而抑制 NAcCRH 神经元则会诱发场所厌恶反应和焦虑状态。NAcCRH 神经元被确定为纹状体末端床核(BNST)的主要 NAc 投射神经元。此外,NAcCRH-BNST通路的激活同样会诱发觉醒和积极的情绪行为。综上所述,我们发现了一种促进与积极情绪状态相关的唤醒的基底前脑CRH通路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Projecting to the Bed Nucleus of the Stria Terminalis Promote Wakefulness and Positive Affective State.

Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Projecting to the Bed Nucleus of the Stria Terminalis Promote Wakefulness and Positive Affective State.

The nucleus accumbens (NAc) plays an important role in various emotional and motivational behaviors that rely on heightened wakefulness. However, the neural mechanisms underlying the relationship between arousal and emotion regulation in NAc remain unclear. Here, we investigated the roles of a specific subset of inhibitory corticotropin-releasing hormone neurons in the NAc (NAcCRH) in regulating arousal and emotional behaviors in mice. We found an increased activity of NAcCRH neurons during wakefulness and rewarding stimulation. Activation of NAcCRH neurons converts NREM or REM sleep to wakefulness, while inhibition of these neurons attenuates wakefulness. Remarkably, activation of NAcCRH neurons induces a place preference response (PPR) and decreased basal anxiety level, whereas their inactivation induces a place aversion response and anxious state. NAcCRH neurons are identified as the major NAc projection neurons to the bed nucleus of the stria terminalis (BNST). Furthermore, activation of the NAcCRH-BNST pathway similarly induced wakefulness and positive emotional behaviors. Taken together, we identified a basal forebrain CRH pathway that promotes the arousal associated with positive affective states.

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来源期刊
Neuroscience bulletin
Neuroscience bulletin NEUROSCIENCES-
CiteScore
7.20
自引率
16.10%
发文量
163
审稿时长
6-12 weeks
期刊介绍: Neuroscience Bulletin (NB), the official journal of the Chinese Neuroscience Society, is published monthly by Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Springer. NB aims to publish research advances in the field of neuroscience and promote exchange of scientific ideas within the community. The journal publishes original papers on various topics in neuroscience and focuses on potential disease implications on the nervous system. NB welcomes research contributions on molecular, cellular, or developmental neuroscience using multidisciplinary approaches and functional strategies. We feature full-length original articles, reviews, methods, letters to the editor, insights, and research highlights. As the official journal of the Chinese Neuroscience Society, which currently has more than 12,000 members in China, NB is devoted to facilitating communications between Chinese neuroscientists and their international colleagues. The journal is recognized as the most influential publication in neuroscience research in China.
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