油橄榄叶提取物对阿脲诱导的 T1 型糖尿病大鼠胎儿的全身/免疫调节作用

IF 1.7 3区 农林科学 Q4 CHEMISTRY, MEDICINAL
Journal of medicinal food Pub Date : 2024-10-01 Epub Date: 2024-07-09 DOI:10.1089/jmf.2024.0021
Alya Mashaal, Heba Y El-Yamany, Hend Abd El-Halim Mansour
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引用次数: 0

摘要

母体葡萄糖是维持胎儿生长的主要营养素。从妊娠早期开始,胎儿长期暴露于高血糖环境中,会加速β细胞自身免疫中刺激-分泌耦合机制的成熟,从而导致1型糖尿病(T1DM)早期的高胰岛素血症。目前,糖尿病(DM)是妊娠期最常见的内科并发症,在年轻女性中,明显糖尿病和未确诊高血糖的发病率正在上升。尽管传统药物对治疗糖尿病有效,但价格昂贵且有副作用。因此,草药将结合替代疗法,并且更有效、毒性更低。由于橄榄叶(Olea europaea)含有生物活性成分,因此经常被用作药用植物;然而,人们对这种植物如何影响糖尿病患者的免疫系统却知之甚少。目前的研究使用阿脲诱导的 T1DM 妊娠母鼠模型来研究橄榄叶的抗糖尿病特性和胚胎安全性。40 只成年雌性 Sprague Dawley 大鼠被分成以下四组:非糖尿病组、糖尿病组、橄榄组和糖尿病-橄榄组。所有母鼠均在怀孕第 20 天被处死,并收集胎儿进行进一步研究。在糖尿病孕母中,胎儿具有系统性调节负效应。当糖尿病组补充橄榄叶提取物后,这些影响明显逆转。研究结果表明,橄榄叶提取物能抑制阿脲介导的致糖尿病效应,并在胚胎发育过程中有效保护全身免疫调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Systemic/Immune-Modulation of Olea europaea Leaf Extract in Fetuses of Alloxan-Induced T1 Diabetic Rats.

Maternal glucose is the principal macronutrient that sustains fetal growth. Prolonged exposure of the fetus to hyperglycemia from the early stages of pregnancy accelerates the maturation of the stimulus-secretion coupling mechanism in β cell autoimmunity, which leads to early hyperinsulinemia in type 1 diabetes mellitus (T1DM). Nowadays, diabetes mellitus (DM) is the most common medical complication of pregnancy, and among young women, the prevalence of overt diabetes and undiagnosed hyperglycemia is rising. Even though conventional medication is effective in treating DM, it is expensive and has harmful side effects. Herbal medicine will thus incorporate alternative therapy and be more effective and less toxic. Due to their bioactive components, olive leaves (Olea europaea) are frequently used medicinally; however, little is known about how this plant affects the immune system when it comes to diabetes. The current study used a pregnant mother rat model of alloxan-induced T1DM to examine the antidiabetic properties and embryonic safety of olive leaves. Forty adult female Sprague Dawley rats were split up into four groups as follows: nondiabetic, diabetic, olive, and diabetic-olive groups. All the mother rats were sacrificed on the 20th day of pregnancy, and fetuses were collected for further investigations. In diabetic pregnant mothers, fetuses had systemic modulation-negative effects. These effects were significantly reversed when the diabetic groups were supplemented with extracts from olive leaves. The findings showed that the olive leaf extract inhibits the diabetogenic effect mediated by alloxan with effective and protective systemic immunomodulation during embryonic development.

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来源期刊
Journal of medicinal food
Journal of medicinal food 医学-食品科技
CiteScore
4.50
自引率
0.00%
发文量
154
审稿时长
4.5 months
期刊介绍: Journal of Medicinal Food is the only peer-reviewed journal focusing exclusively on the medicinal value and biomedical effects of food materials. International in scope, the Journal advances the knowledge of the development of new food products and dietary supplements targeted at promoting health and the prevention and treatment of disease.
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