Deucravacitinib:中重度斑块状银屑病可以预防吗?

Q3 Pharmacology, Toxicology and Pharmaceutics
Manmeet Kaur, Saurav Misra
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引用次数: 0

摘要

银屑病是一种难以治疗的顽固性炎症和自身免疫性疾病。根据年龄、性别、地域、种族、遗传和环境因素的不同,银屑病的发病率估计从 0.27%(95% 置信区间为 0.17 至 0.36)到 11.4%不等。中度至重度银屑病患者通常需要系统治疗,而外用疗法通常对轻度银屑病有效。事实上,光疗常常受到后勤因素的限制,而传统的系统疗法常常因为禁忌症或不良后果的危险而被避免。为了更好地为患者服务,提高他们的生活质量,尤其是为了保持长期疗效,我们仍然需要创新疗法,而创新疗法总是受到欢迎的。Deucravacitinib是第一类口服酪氨酸激酶2(TYK2)抑制剂,具有极高的选择性。通过异构机制,它能稳定 TYK2 假激酶调节域和催化域之间的抑制性连接,而假激酶调节域则没有催化活性。这种药物可用于治疗多种免疫介导的疾病,如炎症性肠病、狼疮、银屑病关节炎和牛皮癣。美国食品和药物管理局已于 2022 年 9 月 9 日批准该药用于治疗适用于系统疗法或光疗的中重度斑块状银屑病成人患者。本文旨在回顾目前有关去氯法替尼治疗银屑病的疗效和安全性的知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Deucravacitinib: moderate-to-severe plaque psoriasis preventable?

Psoriasis is a persistent, inflammatory, and autoimmune condition that is difficult to treat. Estimates of the prevalence of psoriasis in people range from 0.27 % (95 % confidence interval 0.17 to 0.36) to 11.4 %, depending on factors such as age, sex, geography, ethnicity, genetics, and environmental factors. While systemic treatments are typically required for patients with moderate-to-severe instances of psoriasis, topical therapies are frequently effective for treating minor forms. In fact, phototherapy is frequently constrained by logistical considerations, and conventional systemic therapies are frequently avoided due to contraindications or the danger of adverse outcomes. In order to better serve the patient and achieve a greater level of quality of life, especially in order to sustain long-term efficacy, there is still a need for innovative therapies, which are always welcomed. Deucravacitinib is a first-in-class oral tyrosine kinase 2 (TYK2) inhibitor that is extremely selective. Through an allosteric mechanism, it stabilises an inhibitory connection between the regulatory and catalytic domains of TYK2's pseudokinase regulatory domain, which is catalytically inactive. This can be used to treat a variety of immune-mediated conditions, such as inflammatory bowel disease, lupus, psoriatic arthritis, and psoriasis. US-FDA has approved this drug on 9 September 2022 for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. This article aims to review the current knowledge on the efficacy and safety of deucravacitinib for the management of psoriasis.

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来源期刊
Journal of Basic and Clinical Physiology and Pharmacology
Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.90
自引率
0.00%
发文量
53
期刊介绍: The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.
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