João Marcos Carvalho-Silva, Ana Beatriz Vilela Teixeira, Marco Antônio Schiavon, Andréa Cândido Dos Reis
{"title":"含有钒酸银和纳米银颗粒的抗菌凝胶：抗真菌和理化评价。","authors":"João Marcos Carvalho-Silva, Ana Beatriz Vilela Teixeira, Marco Antônio Schiavon, Andréa Cândido Dos Reis","doi":"10.1080/17460913.2024.2366630","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> To develop a β-AgVO<sub>3</sub> gel and evaluate its physicochemical stability and antifungal activity against <i>Candida albicans</i>.<b>Materials & methods:</b> The gel was prepared from the minimum inhibitory concentration (MIC) of β-AgVO<sub>3</sub>. The physicochemical stability was evaluated by centrifugation, accelerated stability (AS), storage (St), pH, syringability, viscosity and spreadability tests and antifungal activity by the agar diffusion.<b>Results:</b> The MIC was 62.5 μg/ml. After centrifugation, AS and St gels showed physicochemical stability. Lower viscosity and higher spreadability were observed for the higher β-AgVO<sub>3</sub> concentration and the minimum force for extrusion was similar for all groups. Antifungal effect was observed only for the β-AgVO<sub>3</sub> gel with 20xMIC.<b>Conclusion:</b> The β-AgVO<sub>3</sub> gel showed physicochemical stability and antifungal activity.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1217-1227"},"PeriodicalIF":2.5000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633398/pdf/","citationCount":"0","resultStr":"{\"title\":\"Antimicrobial gel with silver vanadate and silver nanoparticles: antifungal and physicochemical evaluation.\",\"authors\":\"João Marcos Carvalho-Silva, Ana Beatriz Vilela Teixeira, Marco Antônio Schiavon, Andréa Cândido Dos Reis\",\"doi\":\"10.1080/17460913.2024.2366630\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> To develop a β-AgVO<sub>3</sub> gel and evaluate its physicochemical stability and antifungal activity against <i>Candida albicans</i>.<b>Materials & methods:</b> The gel was prepared from the minimum inhibitory concentration (MIC) of β-AgVO<sub>3</sub>. The physicochemical stability was evaluated by centrifugation, accelerated stability (AS), storage (St), pH, syringability, viscosity and spreadability tests and antifungal activity by the agar diffusion.<b>Results:</b> The MIC was 62.5 μg/ml. After centrifugation, AS and St gels showed physicochemical stability. Lower viscosity and higher spreadability were observed for the higher β-AgVO<sub>3</sub> concentration and the minimum force for extrusion was similar for all groups. Antifungal effect was observed only for the β-AgVO<sub>3</sub> gel with 20xMIC.<b>Conclusion:</b> The β-AgVO<sub>3</sub> gel showed physicochemical stability and antifungal activity.</p>\",\"PeriodicalId\":12773,\"journal\":{\"name\":\"Future microbiology\",\"volume\":\" \",\"pages\":\"1217-1227\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633398/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1080/17460913.2024.2366630\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/9 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/17460913.2024.2366630","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/9 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Antimicrobial gel with silver vanadate and silver nanoparticles: antifungal and physicochemical evaluation.
Aim: To develop a β-AgVO3 gel and evaluate its physicochemical stability and antifungal activity against Candida albicans.Materials & methods: The gel was prepared from the minimum inhibitory concentration (MIC) of β-AgVO3. The physicochemical stability was evaluated by centrifugation, accelerated stability (AS), storage (St), pH, syringability, viscosity and spreadability tests and antifungal activity by the agar diffusion.Results: The MIC was 62.5 μg/ml. After centrifugation, AS and St gels showed physicochemical stability. Lower viscosity and higher spreadability were observed for the higher β-AgVO3 concentration and the minimum force for extrusion was similar for all groups. Antifungal effect was observed only for the β-AgVO3 gel with 20xMIC.Conclusion: The β-AgVO3 gel showed physicochemical stability and antifungal activity.
期刊介绍：
Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.
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