金黄色葡萄球菌、伤寒沙门氏菌、枯草杆菌和大肠埃希氏菌对蜗牛粘液的抗菌敏感性。

Dorcas E Agada, Terdzungwe T Sar, John Adole Ujoh, Linus O Ameh
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引用次数: 0

摘要

背景:多重耐药微生物的出现以及抗击多重耐药感染所面临的挑战是一个公共卫生问题,这增加了从天然来源寻找有效抗生素的难度:本研究旨在确定一些致病细菌对蜗牛粘液的敏感性:方法:采用琼脂井扩散法研究了蜗牛粘液水提取物和乙醇提取物对金黄色葡萄球菌、伤寒沙门氏菌、枯草杆菌和大肠杆菌的抗菌活性:结果表明,所有生物对两种提取物都很敏感,但对水提取物更敏感;在 1000µl/ml 浓度下,水提取物对金黄色葡萄球菌的最大抑菌区为 27.33mm ± 2.51mm,而对大肠杆菌的最小抑菌区为 11.33mm ± 1.53mm。乙醇馏分对伤寒沙门氏菌的最大抑菌区为 15.67±1.15 毫米。对大肠埃希菌的最小抑菌作用为 9.33mm ± 0.58mm。对金黄色葡萄球菌、枯草芽孢杆菌和大肠埃希菌的最小抑菌浓度为 3.125%,对伤寒沙门氏菌的最小抑菌浓度为 6.25%。在使用的浓度下,提取物没有杀菌作用。统计分析显示,水提取物和乙醇提取物对金黄色葡萄球菌、大肠杆菌和伤寒沙门氏菌的处理效果显著(p ≤ 0.05)。结论:这项研究揭示了蜗牛粘液具有抗菌特性,可用作抗微生物剂来防治传染病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibacterial susceptibility of staphylococcus aureus, salmonella typhi, bacillus subtilis and escherichia coli to snail slime.

Background: The emanation of multi-drugs resistant microorganisms and the challenges faced in combating multi-drug resistant infections is a public health issue and this has increased the search for effective antibiotics from natural sources.

Objectives: This work aims to determine the susceptibility of some pathogenic bacterial species to snail slime.

Methods: The antibacterial activity of aqueous and ethanolic snail slime extracts were investigated against Staphylococcus aureus, Salmonella typhi, Bacillus subtilis and Escherichia coli using the agar well diffusion method.

Results: The results showed that all the organisms were sensitive to both extracts but were more susceptible to aqueous extracts; the highest zone of inhibition for aqueous extracts was 27.33mm ± 2.51mm for Staphylococcus aureus at concentration of 1000µl/ml, while the lowest was 11.33mm ± 1.53mm against Escherichia coli. The highest zone of inhibition for ethanolic fraction was 15.67 ± 1.15mm for Salmonella typhi. The lowest inhibition was 9.33mm ± 0.58mm for Escherichia coli. The MIC was 3.125% for Staphylococcus aureus, Bacillus subtilis and Escherichia coli and 6.25% for S. typhi. The extracts were not cidal at the concentrations used. Statistical analysis revealed that the treatments between the aqueous and ethanolic extracts against Staphylococcus aureus, Escherichia coli and Salmonella typhi were significant (p ≤ 0.05). The treatment against B. subtilis showed no significant difference between the two extracts (p > 0.05).

Conclusion: This study has revealed that snail slime possesses antibacterial properties which can be used as anti-microbial agents against infectious diseases.

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