Iolanda Lázaro, Oriol Grau-Rivera, Marc Suárez-Calvet, Karine Fauria, Carolina Minguillón, Mahnaz Shekari, Carles Falcón, Marina García-Prat, Jordi Huguet, José Luis Molinuevo, Juan-Domingo Gispert, Aleix Sala-Vila
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We assessed brain glucose metabolism using [18-F]-fluorodeoxyglucose (FDG) positron emission tomography (PET).</p><p><strong>Results: </strong>Blood ALA directly related to FDG uptake in brain areas known to be affected in AD. Stronger associations were observed in apolipoprotein E ε4 carriers and homozygotes. For DHA, significant direct associations were restricted to amyloid beta-positive tau-positive participants.</p><p><strong>Discussion: </strong>Blood omega-3 directly relate to preserved glucose metabolism in AD-vulnerable brain regions in individuals at increased risk of AD dementia. This adds to the benefits of omega-3 supplementation in the preclinical stage of AD dementia.</p><p><strong>Highlights: </strong>Blood omega-3s were related to brain glucose uptake in participants at risk of Alzheimer's disease (AD) dementia.Complementary associations were observed for omega-3 from marine and plant sources.Foods rich in omega-3 might be useful in early features of AD.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"16 3","pages":"e12596"},"PeriodicalIF":4.0000,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224768/pdf/","citationCount":"0","resultStr":"{\"title\":\"Omega-3 blood biomarkers relate to brain glucose uptake in individuals at risk of Alzheimer's disease dementia.\",\"authors\":\"Iolanda Lázaro, Oriol Grau-Rivera, Marc Suárez-Calvet, Karine Fauria, Carolina Minguillón, Mahnaz Shekari, Carles Falcón, Marina García-Prat, Jordi Huguet, José Luis Molinuevo, Juan-Domingo Gispert, Aleix Sala-Vila\",\"doi\":\"10.1002/dad2.12596\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Brain glucose hypometabolism is a preclinical feature of Alzheimer's disease (AD). 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引用次数: 0
摘要
简介脑葡萄糖代谢不足是阿尔茨海默病（AD）的临床前特征。膳食中的ω-3脂肪酸能促进脑葡萄糖代谢，但临床研究尚处于起步阶段。循环中的ω-3脂肪酸可客观反映膳食摄入量：这是一项横断面研究，研究对象是 320 名认知功能未受损、罹患 AD 痴呆症风险较高的参与者。通过脂质组学，我们测定了血液中二十二碳六烯酸（DHA）和α-亚麻酸（ALA）的水平（omega-3 脂肪酸分别来自海洋和植物）。我们使用[18-F]-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）评估脑葡萄糖代谢：结果：血液中的ALA与已知受AD影响的脑区的FDG摄取量直接相关。在载脂蛋白E ε4携带者和同型基因携带者中观察到更强的相关性。就DHA而言，显著的直接关联仅限于淀粉样β阳性、tau阳性的参与者：讨论：血液中的ω-3与AD痴呆风险增加的个体中AD易感脑区的葡萄糖代谢保护直接相关。这增加了在AD痴呆症临床前阶段补充欧米伽-3的益处：在阿尔茨海默病（AD）痴呆症高危人群中，血液中的欧米伽-3与脑葡萄糖摄取量有关，海洋和植物来源的欧米伽-3具有互补性。
Omega-3 blood biomarkers relate to brain glucose uptake in individuals at risk of Alzheimer's disease dementia.
Introduction: Brain glucose hypometabolism is a preclinical feature of Alzheimer's disease (AD). Dietary omega-3 fatty acids promote brain glucose metabolism, but clinical research is incipient. Circulating omega-3s objectively reflect their dietary intake.
Methods: This was a cross-sectional study in 320 cognitively unimpaired participants at increased risk of AD dementia. Using lipidomics, we determined blood docosahexaenoic (DHA) and alpha-linolenic (ALA) acid levels (omega-3s from marine and plant origin, respectively). We assessed brain glucose metabolism using [18-F]-fluorodeoxyglucose (FDG) positron emission tomography (PET).
Results: Blood ALA directly related to FDG uptake in brain areas known to be affected in AD. Stronger associations were observed in apolipoprotein E ε4 carriers and homozygotes. For DHA, significant direct associations were restricted to amyloid beta-positive tau-positive participants.
Discussion: Blood omega-3 directly relate to preserved glucose metabolism in AD-vulnerable brain regions in individuals at increased risk of AD dementia. This adds to the benefits of omega-3 supplementation in the preclinical stage of AD dementia.
Highlights: Blood omega-3s were related to brain glucose uptake in participants at risk of Alzheimer's disease (AD) dementia.Complementary associations were observed for omega-3 from marine and plant sources.Foods rich in omega-3 might be useful in early features of AD.
期刊介绍：
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
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