乳腺炎的免疫疗法:知识现状、研究差距和前进方向。

IF 7.9 2区 农林科学 Q1 VETERINARY SCIENCES
Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-07-07 DOI:10.1080/01652176.2024.2363626
Afnan Saleem, Sahar Saleem Bhat, Faith A Omonijo, Nazir A Ganai, Eveline M Ibeagha-Awemu, Syed Mudasir Ahmad
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引用次数: 0

摘要

乳腺炎是一种影响奶牛乳腺的炎症。传统的抗生素治疗方法正日益导致抗菌药耐药性等挑战性问题。为了减轻抗生素的不良副作用,人们开始采用替代策略,如利用宿主免疫系统反应的策略(也称为免疫疗法)。治疗牛乳腺炎的免疫疗法旨在通过促进病原体清除和促进组织修复,增强奶牛对病原体的免疫反应。多项研究表明,免疫疗法具有降低乳腺炎发病率、缩短病程和减轻严重程度的潜力。然而,大多数已报道的疗法都缺乏特异性,这阻碍了它们在治疗乳腺炎方面的广泛应用。与此同时,乳腺炎免疫疗法的进步为乳制品行业带来了巨大的希望,有望为传统的抗生素疗法提供有效、可持续的替代品。本综述综述了免疫疗法策略、目前对其的理解以及未来的潜在前景。未来展望的重点应是开发针对单个病原体/病原体群的精准免疫疗法、开发针对抗菌素耐药性的组合疗法以及纳米和全息技术的整合。通过填补研究空白,乳腺炎免疫疗法领域将在乳腺炎的控制、治疗和预防方面取得重大进展,最终造福于动物和人类的健康/福利以及环境健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunotherapy in mastitis: state of knowledge, research gaps and way forward.

Mastitis is an inflammatory condition that affects dairy cow's mammary glands. Traditional treatment approaches with antibiotics are increasingly leading to challenging scenarios such as antimicrobial resistance. In order to mitigate the unwanted side effects of antibiotics, alternative strategies such as those that harness the host immune system response, also known as immunotherapy, have been implemented. Immunotherapy approaches to treat bovine mastitis aims to enhance the cow's immune response against pathogens by promoting pathogen clearance, and facilitating tissue repair. Various studies have demonstrated the potential of immunotherapy for reducing the incidence, duration and severity of mastitis. Nevertheless, majority of reported therapies are lacking in specificity hampering their broad application to treat mastitis. Meanwhile, advancements in mastitis immunotherapy hold great promise for the dairy industry, with potential to provide effective and sustainable alternatives to traditional antibiotic-based approaches. This review synthesizes immunotherapy strategies, their current understanding and potential future perspectives. The future perspectives should focus on the development of precision immunotherapies tailored to address individual pathogens/group of pathogens, development of combination therapies to address antimicrobial resistance, and the integration of nano- and omics technologies. By addressing research gaps, the field of mastitis immunotherapy can make significant strides in the control, treatment and prevention of mastitis, ultimately benefiting both animal and human health/welfare, and environment health.

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来源期刊
Veterinary Quarterly
Veterinary Quarterly VETERINARY SCIENCES-
CiteScore
13.10
自引率
1.60%
发文量
18
审稿时长
>24 weeks
期刊介绍: Veterinary Quarterly is an international open access journal which publishes high quality review articles and original research in the field of veterinary science and animal diseases. The journal publishes research on a range of different animal species and topics including: - Economically important species such as domesticated and non-domesticated farm animals, including avian and poultry diseases; - Companion animals (dogs, cats, horses, pocket pets and exotics); - Wildlife species; - Infectious diseases; - Diagnosis; - Treatment including pharmacology and vaccination
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