评估与原发性免疫缺陷儿童静脉注射免疫球蛋白替代疗法相关的自身抗体。

IF 4.1 4区 医学 Q2 IMMUNOLOGY
Scandinavian Journal of Immunology Pub Date : 2024-11-01 Epub Date: 2024-07-07 DOI:10.1111/sji.13396
Murat Özer, Seher Tekeli, Selçuk Doğan, Sema Çetin, Rıdvan Selen, Caner Aytekin
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引用次数: 0

摘要

众所周知,用于治疗原发性免疫缺陷病(PID)的免疫球蛋白替代疗法(IgRT)会导致自身抗体的被动转移,但目前还没有数据表明这些抗体会导致患者出现临床症状。本研究旨在调查接受 IgRT 治疗的 PID 患者体内是否存在自身抗体及其临床相关性。研究纳入了2012年1月1日至2021年12月31日期间在本院免疫诊所确诊为PID并接受IgRT治疗的儿科患者。对这些患者的病历进行回顾性分析,并筛查自身抗体。48例患者至少进行了一次自身抗体筛查。在这些病例中,29 例(60.4%)至少有一种自身抗体呈阳性。其中,23 例抗血小板生成素检测呈阳性,9 例抗 TG 检测呈阳性,2 例抗血小板生成素和抗 TG 检测均呈阳性。其中只有两名患者被确诊为桥本氏甲状腺炎。在30例病例中,筛查出了与乳糜泻(CD)相关的自身抗体,其中有5例至少有一种抗体呈阳性;但乳糜泻并未得到确诊。我们的研究结果表明,自身抗体被动转移到 IgRT 患者身上不会引起任何明显的临床症状。此外,在 PID 病例中,从 IgRT 患者的血液中检测到自身抗体可能会导致误诊。对接受 IgRT 的 PID 患者进行自身抗体筛查,可能无法准确检测出自身免疫性疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of autoantibodies associated with intravenous immunoglobulin replacement therapy in children with primary immunodeficiency.

While it is known that immunoglobulin replacement therapy (IgRT) used in the treatment of primary immunodeficiency disorders (PIDs) can lead to the passive transfer of autoantibodies, there is no data indicating that these antibodies can cause clinical symptoms in patients. This study aimed to investigate the presence of autoantibodies and their clinical correlation in patients diagnosed with PIDs receiving IgRT. Paediatric patients who were diagnosed with PIDs, and administered IgRT at our immunology clinic between 1 January 2012 and 31 December 2021, were included in the study. The medical records of these patients were retrospectively analysed, and autoantibodies were screened. Autoantibody screening was conducted at least once in 48 cases. Among these cases, 29 cases (60.4%) demonstrated positivity for at least one of the autoantibodies screened in the study. Among these cases, 23 tested positive for anti-TPO, 9 for anti-TG and 2 for both anti-TPO and anti-TG. Only two of these patients were confirmed to have Hashimoto's thyroiditis. In 30 cases, autoantibodies related to Celiac disease (CD) were screened, with at least one being positive in five different cases; CD was not confirmed. The results of our study suggest that passive transfer of autoantibodies to patients with IgRT does not cause any significant clinical findings. In addition, in cases of PID, autoantibodies detected in the blood passed to patients with IgRT can lead to misdiagnosis. Screening for autoantibodies in patients with PID undergoing IgRT may not yield accurate results in terms of detecting autoimmune diseases.

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来源期刊
CiteScore
7.70
自引率
5.40%
发文量
109
审稿时长
1 months
期刊介绍: This peer-reviewed international journal publishes original articles and reviews on all aspects of basic, translational and clinical immunology. The journal aims to provide high quality service to authors, and high quality articles for readers. The journal accepts for publication material from investigators all over the world, which makes a significant contribution to basic, translational and clinical immunology.
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