老年人呼吸道肌肉疏松症相关因素的探索性研究

IF 2.4 Q2 RESPIRATORY SYSTEM

Respiratory investigation Pub Date : 2024-07-06 DOI:10.1016/j.resinv.2024.06.009

Takuya Umehara , Akinori Kaneguchi , Takahiro Yamasaki , Nobuhiro Kito

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引用次数: 0

摘要

背景：呼吸性肌肉疏松症的诊断标准最近已有报道。然而，目前还没有研究阐明呼吸性肌肉疏松症患者四肢骨骼肌受损的特征。本研究旨在探讨与长者可能患上呼吸性肌肉疏松症有关的因素，包括骨骼肌：研究将受试者分为可能呼吸性肌肉疏松症组和非呼吸性肌肉疏松症组。可能的呼吸性肌肉疏松症是指同时存在呼吸肌无力（低于根据年龄、性别和身高计算出的预测值）和骨骼肌质量低（男性为 2，女性为 5.7 kg/m2）。对以下因素进行了测量：呼吸肌力量、骨骼肌质量指数、股直肌肌肉厚度和回声强度、细胞外水与细胞内水比率、手部握力、5次坐立、膝关节伸展力量、骨矿物质密度、年龄、性别、体重指数、虚弱程度、有无病史、有无习惯性运动、开始运动后的时间以及每次运动的小时数。采用层次逻辑回归分析法对可能患有呼吸道肌肉疏松症的相关受试者进行了分析：结果：共纳入 26 名可能患有呼吸性肌肉疏松症的受试者和 54 名患有非呼吸性肌肉疏松症的受试者。层次逻辑回归分析表明，回声强度是预测呼吸道肌肉疏松症的重要指标。回声强度的几率比为 2.54（95% 置信区间：1.04-6.23）：我们的研究结果表明，下肢肌肉质量的下降与可能的呼吸肌疏松症有关。

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Exploratory study of factors associated with probable respiratory sarcopenia in elderly subjects

Background

The diagnostic criteria for respiratory sarcopenia have been recently reported. However, no studies have clarified the characteristics of skeletal muscle impairment of the limbs in subjects with respiratory sarcopenia. This study aimed to explore the factors, including skeletal muscle, associated with probable respiratory sarcopenia in elderly subjects.

Methods

Subjects were classified into the probable respiratory sarcopenia group and nonrespiratory sarcopenia group. Probable respiratory sarcopenia was defined as the concurrent presence of respiratory muscle weakness (as less than the predicted value calculated from age, sex, and height) and low skeletal muscle mass (<7.0 kg/m² in males and 5.7 kg/m² in females). The following factors were measured: respiratory muscle strength, skeletal muscle mass index, muscle thickness and echo intensity of the rectus femoris, extracellular-to-intracellular water ratio, hand grip strength, 5 sit-to-stand, knee extension strength, bone mineral density, age, sex, body mass index, degree of frailty, presence or absence of medical history, presence or absence of habitual exercise, period of time since the start of exercise, and number of hours of exercise at a time. The association subjects with probable respiratory sarcopenia were analyzed using hierarchical logistic regression analysis.

Results

Twenty-six with probable respiratory sarcopenia and 54 with nonrespiratory sarcopenia were included. Hierarchical logistic regression analysis revealed that echo intensity was a significant predictor of probable respiratory sarcopenia. The odds ratio for echo intensity was 2.54 (95% confidence interval: 1.04–6.23).