从巴豆莽龙叶中提取的结构多样的二萜类化合物及其抗糖尿病活性。

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2024-07-05 DOI:10.1016/j.phytochem.2024.114206

Zhi-Yong Jiang , Qi Niu , Hao-Xin Wang , Hao-Nan Xu , Hong-Xi Xie , Lin Chen , Rong Chen , Hong-Lei Zhang , Lu Gao , Ai-Xue Zuo , Hong-Ping He

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引用次数: 0

摘要

从 Croton mangelong 的叶子中分离出 18 种化合物，包括 11 种以前未曾描述过的二萜类化合物。通过 HRESIMS、IR、NMR、X 射线衍射和 ECD 光谱分析确定了这些化合物的结构。在胰岛素抵抗（IR）3T3-L1 脂肪细胞中检测了所有分离物的抗高血糖活性，并在体内检测了化合物 4 的抗糖尿病活性。结果表明，在 30 毫克/千克的剂量下，化合物 4 能有效降低糖尿病 SD 大鼠的血糖水平。

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Structurally diverse diterpenoids from the leaves of Croton mangelong and their anti-diabetic activity

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Structurally diverse diterpenoids from the leaves of Croton mangelong and their anti-diabetic activity

Eighteen compounds including eleven previously undescribed diterpenes were isolated from the leaves of Croton mangelong. The structures were determined by HRESIMS, IR, NMR, X-ray diffraction and ECD spectroscopic analysis. All isolates were assayed for their anti-hyperglycemic activities in insulin resistance (IR) 3T3-L1 adipocytes, and compound 4 was tested for its anti-diabetic activity in vivo. Results suggested compound 4 could effectively reduce blood glucose level in diabetic SD rats in a dose of 30 mg/kg.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.