膳食果胶和菊粉:通过肠道微生物组恢复和 CD4+ T 细胞重建治疗胶原蛋白诱导的关节炎的一种有前途的辅助补充剂。

IF 4.8 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
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引用次数: 0

摘要

富含纤维的膳食策略已被证明能为类风湿关节炎(RA)患者带来益处。然而,高纤维饮食(HFD)减轻类风湿性关节炎自身免疫性的具体机制仍然难以捉摸。在此,我们研究了富含果胶和菊粉的高纤维饮食对胶原诱导的关节炎(CIA)的影响。我们发现,高纤维食物能通过调节 Th17/Treg 平衡显著缓解 CIA 小鼠的关节炎。HFD 对 T 细胞异常分化的纠正与肠道微生物群的调节有关,它增加了粪便中丁酸盐的丰度。同时,在饮用水中添加丁酸盐反映了高纤维食物对改善 CIA 的影响,包括缓解关节炎、调节肠道屏障完整性和恢复 Th17/Treg 平衡。丁酸盐以 AMPK 依赖性方式重塑了 CD4+ T 细胞的代谢轮廓。我们的研究强调了膳食干预在纠正肠道微生物群以控制RA方面的重要性,并解释了膳食衍生的微生物代谢物如何影响RA的免疫炎症反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dietary pectin and inulin: A promising adjuvant supplement for collagen-induced arthritis through gut microbiome restoration and CD4+ T cell reconstitution

Dietary strategies rich in fiber have been demonstrated to offer benefits to individuals afflicted with rheumatoid arthritis (RA). However, the specific mechanisms through which a high-fiber diet (HFD) mitigates RA's autoimmunity remain elusive. Herein, we investigate the influence of pectin- and inulin-rich HFD on collagen-induced arthritis (CIA). We establish that HFD significantly alleviates arthritis in CIA mice by regulating the Th17/Treg balance. The rectification of aberrant T cell differentiation by the HFD is linked to the modulation of gut microbiota, augmenting the abundance of butyrate in feces. Concurrently, adding butyrate to the drinking water mirrors the HFD's impact on ameliorating CIA, encompassing arthritis mitigation, regulating intestinal barrier integrity, and restoring the Th17/Treg equilibrium. Butyrate reshapes the metabolic profile of CD4+ T cells in an AMPK-dependent manner. Our research underscores the importance of dietary interventions in rectifying gut microbiota for RA management and offers an explanation of how diet-derived microbial metabolites influence RA's immune-inflammatory-reaction.

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来源期刊
Journal of Nutritional Biochemistry
Journal of Nutritional Biochemistry 医学-生化与分子生物学
CiteScore
9.50
自引率
3.60%
发文量
237
审稿时长
68 days
期刊介绍: Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology. Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.
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