从 Aconitum nagarum 的根中提取的两种新的二萜生物碱及其细胞毒性活性。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-07-08 DOI:10.1080/10286020.2024.2373326

Jiang Hu, Ren Ji, Guang-Rong Yang, Tao Lv, Qiang Li, Feng Gao

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引用次数: 0

摘要

通过对 Aconitum nagarum 的根部进行化学研究，发现了两种未曾描述过的 C19-二萜生物碱 nagarumines D 和 E（1 和 2）。通过一维和二维（1H-1H COSY、HMQC 和 HMBC）核磁共振光谱以及 HR-ESI-MS 等光谱方法阐明了新化合物的结构。在体外测试了这两种分离出的生物碱对五种胃肿瘤细胞系的细胞毒性活性。结果表明，化合物 2 对几种人类癌细胞株具有一定的细胞毒性，其 IC50 值小于 20.0 μM。

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Two new diterpenoid alkaloids from the roots of Aconitum nagarum and their cytotoxic activity.

A chemical investigation on the roots of Aconitum nagarum afforded two undescribed C₁₉-diterpenoid alkaloids nagarumines D and E (1 and 2). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (¹H-¹H COSY, HMQC, and HMBC) NMR spectroscopy, as well as HR-ESI-MS. The two isolated alkaloids were tested in vitro for cytotoxic activity against five gastric tumor cell lines. Consequently, compound 2 exhibited some cytotoxicities against several human cancer cell lines with IC₅₀ value less than 20.0 μM.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.