系统性硬化症相关间质性肺病患者血清 Krebs von den Lungen-6 水平的季节性波动。

IF 2.4 4区 医学 Q2 RHEUMATOLOGY
Hikaru Hirose, Tomoaki Higuchi, Kae Takagi, Akiko Tochimoto, Yuki Ichimura, Masayoshi Harigai, Yasushi Kawaguchi
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引用次数: 0

摘要

目的:评估季节变化是否会影响系统性硬化症相关间质性肺病(SSc-ILD)患者血清克雷布斯-冯登肺素-6(KL-6)水平的波动:夏季定义为 7 月至 9 月,冬季定义为 12 月至 2 月。研究在 2015 年至 2016 年期间进行,重点关注这两个季节。使用胸部计算机断层扫描对ILD诊断和ILD进展时间进行评估。在SSc-ILD患者中,纳入了2015年冬季、2015年夏季和2016年冬季有血清KL-6和乳酸脱氢酶(LDH)水平数据的患者。排除了患有可能影响血清KL-6水平的合并症的患者:在60例SSc-ILD患者中,52例(86.7%)ILD稳定,5例(8.3%)ILD恶化,3例(5.0%)ILD改善。血清 KL-6 水平冬季显著高于夏季(2015 年冬季 vs. 2015 年夏季:649 U/mL对585 U/mL,P 结论:在 SSc-ILD 患者中观察到了血清 KL-6 水平的季节性波动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seasonal fluctuation of serum Krebs von den Lungen-6 levels in systemic sclerosis-associated interstitial lung disease

Aim

To evaluate whether seasonal changes influence fluctuations in serum Krebs von den Lungen-6 (KL-6) levels in systemic sclerosis-related interstitial lung disease (SSc-ILD).

Methods

Summer was defined as the period between July and September, and winter as between December and February. The study was conducted between 2015 and 2016, with a focus on these two seasons. A diagnosis of ILD and ILD progression overtime were evaluated using chest computed tomography. Among patients with SSc-ILD, those with data on serum KL-6 and lactate dehydrogenase (LDH) levels in the 2015 winter, 2015 summer, and 2016 winter seasons were included. Patients with comorbidities that could affect serum KL-6 levels were excluded.

Results

Of 60 patients with SSc-ILD, 52 (86.7%) had stable ILD, 5 (8.3%) had worsened ILD, and 3 (5.0%) had improved ILD. Serum KL-6 levels were significantly higher during the winter than those during the summer (2015 winter vs. 2015 summer: 649 U/mL vs. 585 U/mL, p < .0001; 2016 winter vs. 2015 summer: 690 U/mL vs. 585 U/mL, p < .0001). No significant differences were observed between the winters of 2015 and 2016 (649 U/mL vs. 690 U/mL, p = .78). However, serum LDH levels did not exhibit seasonal fluctuations (2015 winter vs. 2015 summer: 203 U/L vs. 199 U/L, p = .3; 2016 winter vs. 2015 summer: 201 U/L vs. 199 U/L, p = .6; 2015 winter vs. 2016 winter: 203 U/L vs. 201 U/L, p = .24).

Conclusion

Seasonal fluctuations in serum KL-6 levels were observed in patients with SSc-ILD.

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来源期刊
CiteScore
3.70
自引率
4.00%
发文量
362
审稿时长
1 months
期刊介绍: The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.
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