炎症性皮肤病中的代谢组学和脂质组学指纹--特应性皮炎、化脓性扁桃体炎和斑块状银屑病的系统照明。

IF 4.5 3区 医学 Q2 IMMUNOLOGY
S. Rischke , S.M.G. Schäfer , A. König , T. Ickelsheimer , M. Köhm , L. Hahnefeld , A. Zaliani , K. Scholich , A. Pinter , G. Geisslinger , F. Behrens , R. Gurke
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引用次数: 0

摘要

自身炎症性皮肤病给患者带来了相当大的症状和精神负担,并对医疗支出造成压力。虽然大多数明显的症状表现在皮肤上,但全身性炎症值得进行更深入的分析。我们的目的是找出疾病与健康对照组之间代谢组和脂质组中的系统共性以及差异。我们使用从特应性皮炎、斑块型银屑病或化脓疱性皮炎患者或健康对照组采集的血浆样本,进行了脂质组和代谢组 LC-MS 分析。血浆图谱显示,在所有三种炎症性疾病中,非酶性抗氧化防御发生了明显变化,半胱氨酸代谢成为潜在失调的中心。脂质网络富集还表明,与炎症信号转导中的关键作用相关的脂质介质具有疾病特异性。这些发现将有助于厘清自身免疫性皮肤病的系统成分,为个体化治疗和改善预后铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolomic and lipidomic fingerprints in inflammatory skin diseases – Systemic illumination of atopic dermatitis, hidradenitis suppurativa and plaque psoriasis

Auto-inflammatory skin diseases place considerable symptomatic and emotional burden on the affected and put pressure on healthcare expenditures. Although most apparent symptoms manifest on the skin, the systemic inflammation merits a deeper analysis beyond the surface. We set out to identify systemic commonalities, as well as differences in the metabolome and lipidome when comparing between diseases and healthy controls. Lipidomic and metabolomic LC-MS profiling was applied, using plasma samples collected from patients suffering from atopic dermatitis, plaque-type psoriasis or hidradenitis suppurativa or healthy controls. Plasma profiles revealed a notable shift in the non-enzymatic anti-oxidant defense in all three inflammatory disorders, placing cysteine metabolism at the center of potential dysregulation. Lipid network enrichment additionally indicated the disease-specific provision of lipid mediators associated with key roles in inflammation signaling. These findings will help to disentangle the systemic components of autoimmune dermatological diseases, paving the way to individualized therapy and improved prognosis.

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来源期刊
Clinical immunology
Clinical immunology 医学-免疫学
CiteScore
12.30
自引率
1.20%
发文量
212
审稿时长
34 days
期刊介绍: Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.
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