Yuanhong Min , Haixia Kong , Tingting Ni , Shiyue Wu , Jiangling Wu , Yi Wang , Wensheng Fu , Pu Zhang
{"title":"用于智能手机比色传感的具有高氧化酶模拟活性的二维 β-MnOOH 纳米片。","authors":"Yuanhong Min , Haixia Kong , Tingting Ni , Shiyue Wu , Jiangling Wu , Yi Wang , Wensheng Fu , Pu Zhang","doi":"10.1016/j.colsurfb.2024.114075","DOIUrl":null,"url":null,"abstract":"<div><p>Manganese (Mn) is a versatile transition element with diverse oxidation states and significant biological importance. Mn-based nanozymes have emerged as promising catalysts in various applications. However, the direct use of manganese oxides as oxidase mimics remains limited and requires further improvement. In this study, we focus on hydroxylated manganese (MnOOH), specifically the layered form β-MnOOH which exhibits unique electronic and structural characteristics. The two-dimensional β-MnOOH nanosheets were synthesized through a hydrothermal approach and showed remarkable oxidase-like activity. These nanosheets effectively converted the oxidase substrate, 3,3′,5,5′-tetramethylbenzidine (TMB), into its oxidized form by initiating the conversion of dissolved oxygen into ·O<sub>2</sub><sup>−</sup>, <sup>1</sup>O<sub>2</sub> and ·OH. However, in the presence of L-cysteine (L-Cys), the catalytic activity of β-MnOOH was significantly inhibited, enabling highly sensitive detection of L-Cys. This sensing strategy was successfully applied for smartphone-based L-Cys assay, offering potential utility in the diagnosis of Cys-related diseases. The exploration of layered β-MnOOH nanosheets as highly active oxidase mimics opens up new possibilities for catalytic and biomedical applications.</p></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":null,"pages":null},"PeriodicalIF":5.4000,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Two-dimensional β-MnOOH nanosheets with high oxidase-mimetic activity for smartphone-based colorimetric sensing\",\"authors\":\"Yuanhong Min , Haixia Kong , Tingting Ni , Shiyue Wu , Jiangling Wu , Yi Wang , Wensheng Fu , Pu Zhang\",\"doi\":\"10.1016/j.colsurfb.2024.114075\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Manganese (Mn) is a versatile transition element with diverse oxidation states and significant biological importance. Mn-based nanozymes have emerged as promising catalysts in various applications. However, the direct use of manganese oxides as oxidase mimics remains limited and requires further improvement. In this study, we focus on hydroxylated manganese (MnOOH), specifically the layered form β-MnOOH which exhibits unique electronic and structural characteristics. The two-dimensional β-MnOOH nanosheets were synthesized through a hydrothermal approach and showed remarkable oxidase-like activity. These nanosheets effectively converted the oxidase substrate, 3,3′,5,5′-tetramethylbenzidine (TMB), into its oxidized form by initiating the conversion of dissolved oxygen into ·O<sub>2</sub><sup>−</sup>, <sup>1</sup>O<sub>2</sub> and ·OH. However, in the presence of L-cysteine (L-Cys), the catalytic activity of β-MnOOH was significantly inhibited, enabling highly sensitive detection of L-Cys. This sensing strategy was successfully applied for smartphone-based L-Cys assay, offering potential utility in the diagnosis of Cys-related diseases. The exploration of layered β-MnOOH nanosheets as highly active oxidase mimics opens up new possibilities for catalytic and biomedical applications.</p></div>\",\"PeriodicalId\":279,\"journal\":{\"name\":\"Colloids and Surfaces B: Biointerfaces\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2024-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Colloids and Surfaces B: Biointerfaces\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0927776524003345\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloids and Surfaces B: Biointerfaces","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0927776524003345","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOPHYSICS","Score":null,"Total":0}
Two-dimensional β-MnOOH nanosheets with high oxidase-mimetic activity for smartphone-based colorimetric sensing
Manganese (Mn) is a versatile transition element with diverse oxidation states and significant biological importance. Mn-based nanozymes have emerged as promising catalysts in various applications. However, the direct use of manganese oxides as oxidase mimics remains limited and requires further improvement. In this study, we focus on hydroxylated manganese (MnOOH), specifically the layered form β-MnOOH which exhibits unique electronic and structural characteristics. The two-dimensional β-MnOOH nanosheets were synthesized through a hydrothermal approach and showed remarkable oxidase-like activity. These nanosheets effectively converted the oxidase substrate, 3,3′,5,5′-tetramethylbenzidine (TMB), into its oxidized form by initiating the conversion of dissolved oxygen into ·O2−, 1O2 and ·OH. However, in the presence of L-cysteine (L-Cys), the catalytic activity of β-MnOOH was significantly inhibited, enabling highly sensitive detection of L-Cys. This sensing strategy was successfully applied for smartphone-based L-Cys assay, offering potential utility in the diagnosis of Cys-related diseases. The exploration of layered β-MnOOH nanosheets as highly active oxidase mimics opens up new possibilities for catalytic and biomedical applications.
期刊介绍:
Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields.
Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication.
The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.