液滴的界面变性简化了载药蛋白质纳米胶囊的形成，从而增强了细胞的免疫反应。

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2024-07-08 DOI:10.1002/advs.202403668

Sharafudheen Pottanam Chali, Jinhong Kang, Michael Fichter, Kai Robert Speth, Volker Mailänder, Katharina Landfester

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引用次数: 0

摘要

纳米胶囊能以高封装含量和效率对治疗药物进行多组分封装，这对癌症免疫疗法至关重要。过去，人们使用化学交联法合成纳米胶囊，这可能会阻碍监管审批程序。因此，通过一种被称为 "液滴界面烘烤 "的工艺，利用蛋白质变性，省去了化学交联，从而开发出一种新型蛋白质纳米胶囊。这种外壳中含有抗原的蛋白质纳米胶囊和封装药物的组合显示出细胞免疫反应的增强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Interfacial Denaturation at the Droplet Simplifies the Formation of Drug-Loaded Protein Nanocapsules to Enhance Immune Response of Cells.

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Interfacial Denaturation at the Droplet Simplifies the Formation of Drug-Loaded Protein Nanocapsules to Enhance Immune Response of Cells.

Nanocapsules enable multicomponent encapsulation of therapeutic cargoes with high encapsulation content and efficiency, which is vital for cancer immunotherapy. In the past, chemical crosslinking is used to synthesize nanocapsules, which can impede the regulatory approval process. Therefore, a new class of protein nanocapsules is developed by eliminating the need for chemical crosslinking by utilizing protein denaturation through a process that is referred to as "baking at the droplet interface". Such protein nanocapsules with antigens incorporated in the shell and a combination of encapsulated drugs showed an enhancement in the immune response of cells.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.