用于工程酶仿生材料的多分子组件自组装

IF 14 Q1 CHEMISTRY, MULTIDISCIPLINARY
Shichao Xu, Yuanxi Liu, Baoli Zhang, Shan Li, Xiangyu Ye, Zhen-Gang Wang
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引用次数: 0

摘要

天然酶具有复杂的三维结构,能以超乎寻常的精度和速度促进各种生化反应。酶的催化能力源于其活性位点的独特结构,在活性位点上,功能基团与辅助因子(有机或离子)协作或辅助,特异性地结合底物并催化转化。受酶的结构-功能关系启发,超分子自组装这种自下而上的纳米制造方法已被用于制造仿酶催化剂。然而,准确复制酶的活性位点是一项艰巨的挑战,主要是因为模仿天然蛋白质折叠的复杂性错综复杂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Self-Assembly of Multimolecular Components for Engineering Enzyme-Mimetic Materials

Self-Assembly of Multimolecular Components for Engineering Enzyme-Mimetic Materials
Natural enzymes, with their intricate three-dimensional structures, facilitate a wide array of biochemical reactions with exceptional precision and speed. The catalytic capabilities of enzymes arise from the distinctive structures of their active sites, where functional groups collaborate or aid cofactors (organic or ionic) in binding substrates with specificity and catalyzing transformations. Inspired by the structure–function relationship of enzymes, supramolecular self-assembly, a bottom-up approach in nanofabrication, has been employed to create enzyme-mimetic catalysts. However, accurately replicating enzymatic active sites poses a formidable challenge, primarily because of the intricacies in mimicking the complexity of natural protein folding.
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CiteScore
17.70
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