线粒体外膜的孔形成 VDAC 蛋白：调节和病理生理作用

IF 2.3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry (Moscow) Pub Date : 2024-07-04 DOI:10.1134/s0006297924060075

Natalia V. Belosludtseva, Mikhail V. Dubinin, Konstantin N. Belosludtsev

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引用次数: 0

摘要

摘要线粒体外膜的电压依赖性阴离子通道（VDAC1-3）是一个孔形成β管蛋白家族，在细胞质和线粒体之间对小分子和离子进行可控的 "过滤"。由于在闭合和开放状态之间的构象转换以及与细胞质和线粒体蛋白的相互作用，VDACs 不仅调节线粒体膜对主要代谢产物和离子的通透性，还参与控制细胞内的基本过程和病理状态。这篇综述讨论了有关 VDAC 蛋白的分子结构、调控机制和病理生理作用的新数据，以及该领域的未来研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pore-Forming VDAC Proteins of the Outer Mitochondrial Membrane: Regulation and Pathophysiological Role

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Pore-Forming VDAC Proteins of the Outer Mitochondrial Membrane: Regulation and Pathophysiological Role

Abstract

Voltage-dependent anion channels (VDAC1-3) of the outer mitochondrial membrane are a family of pore-forming β-barrel proteins that carry out controlled “filtration” of small molecules and ions between the cytoplasm and mitochondria. Due to the conformational transitions between the closed and open states and interaction with cytoplasmic and mitochondrial proteins, VDACs not only regulate the mitochondrial membrane permeability for major metabolites and ions, but also participate in the control of essential intracellular processes and pathological conditions. This review discusses novel data on the molecular structure, regulatory mechanisms, and pathophysiological role of VDAC proteins, as well as future directions in this area of research.

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来源期刊

Biochemistry (Moscow) 生物-生化与分子生物学

CiteScore

4.70

自引率

3.60%

发文量

139

审稿时长

2 months

期刊介绍： Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).