用放射疗法治疗达里尔病：病例报告和文献综述

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-07-05 DOI:10.2147/ccid.s473099

Xinzhou Liu, Xiuhuan Wang, Jianke Li, Xiaofeng Shan, Zhongxiang Shi

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引用次数: 0

摘要

摘要：达里尔病（Darier's disease，DD）是一种常染色体显性遗传性皮肤病，以角化过度的丘疹为特征，常伴有脱屑和结痂。由于缺乏有效的治疗方法，目前只有针对症状的治疗方法，因此治疗达里尔病面临着巨大的挑战。本研究介绍了一例难治性 DD 病例，患者对既有的药物治疗反应不佳，但接受低剂量浅层 X 射线放射治疗（SRT）后病情有所好转。放射治疗采用单次 200 cGy 的剂量，明显改善了病情。考虑到不同程度的副作用、后遗症以及接受中等剂量辐射后患辐射诱发癌症的风险，我们可以考虑在治疗顽固性 DD 时，首先尝试使用低剂量辐射，以减轻这些不良副作用。如果由于反应不充分而需要加大剂量或增加疗程，则必须仔细评估风险和益处，并与患者进行讨论：达里尔病、浅表 X 射线、低剂量辐射、SRT-100

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Treatment of Darier Disease with Radiation Therapy: Case Report and Literature Review

Abstract: Darier’s disease (DD) is an autosomal dominant genodermatosis characterized by hyperkeratotic papules, often accompanied by scaling and crusting. Managing DD presents significant challenges due to the absence of an effective cure, with only symptom targeting treatments currently available. This study presents a case of refractory DD that showed poor response to established pharmacological treatments but demonstrated improvement with low-dose superficial X-ray radiotherapy (SRT). The radiation was delivered as a single 200 cGy treatment, which visibly improved the condition. Considering the different degrees of side effects, sequelae, and risk of developing radiation-induced cancer after exposure to moderate levels of radiation, it may be considered that we attempt to treat recalcitrant DD initially by applying a low dose of radiation in order to mitigate these undesired side effects. If larger doses or additional courses are necessary due to inadequate response, the risks and benefits must be carefully evaluated and discussed with patients.

Keywords: Darier disease, superficial X-ray, low-dose of radiation, SRT-100

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.