DNA 修复酶的 N-糖苷键裂解策略

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY

Moscow University Chemistry Bulletin Pub Date : 2024-06-04 DOI:10.3103/S0027131424700044

A. V. Endutkin, D. O. Zharkov

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引用次数: 0

摘要

摘要DNA糖基化酶是一种能水解受损核苷酸的N-糖苷键，启动碱基切除DNA修复过程的酶。这类酶至少有八种结构类别，它们在底物特异性和催化机制方面各不相同。本综述探讨了人类和细菌 DNA 糖基化酶的机制，这些酶保护基因组免受主要类型的 DNA 损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Strategies of N-Glycosidic Bond Cleavage by DNA Repair Enzymes

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Strategies of N-Glycosidic Bond Cleavage by DNA Repair Enzymes

DNA glycosylases are enzymes that hydrolyze the N-glycosidic bond of damaged nucleotides, initiating the process of base excision DNA repair. There are at least eight structural classes of these enzymes, differing in both their substrate specificity and the mechanism of catalysis. The review examines the mechanisms of human and bacterial DNA glycosylases that protect the genome from the major types of DNA damage.

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来源期刊

Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.30

自引率

14.30%

发文量

期刊介绍： Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.