{"title":"俄罗斯科学院舒布尼科夫晶体学研究所的蛋白质 X 射线结构研究","authors":"I. P. Kuranova, A. A. Lashkov, V. R. Samygina","doi":"10.1134/S1063774524600078","DOIUrl":null,"url":null,"abstract":"<p>The development and formation of X-ray crystallography of macromolecules, or protein crystallography, is one of the most important achievements of science in the 20th century. The possibility of establishing the three-dimensional structures of macromolecules of proteins and nucleic acids at atomic level has ensured the rapid development of molecular biology, biochemistry, bioengineering, and biotechnology and allowed researchers to reach the modern level of pharmacology. The review considers the results of studies of protein structures performed at the Shubnikov Institute of Crystallography of the Russian Academy of Sciences from the 1960s up to now.</p>","PeriodicalId":527,"journal":{"name":"Crystallography Reports","volume":"69 2","pages":"121 - 138"},"PeriodicalIF":0.6000,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"X-ray Structural Studies of Proteins at the Shubnikov Institute of Crystallography of the Russian Academy of Sciences\",\"authors\":\"I. P. Kuranova, A. A. Lashkov, V. R. Samygina\",\"doi\":\"10.1134/S1063774524600078\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The development and formation of X-ray crystallography of macromolecules, or protein crystallography, is one of the most important achievements of science in the 20th century. The possibility of establishing the three-dimensional structures of macromolecules of proteins and nucleic acids at atomic level has ensured the rapid development of molecular biology, biochemistry, bioengineering, and biotechnology and allowed researchers to reach the modern level of pharmacology. The review considers the results of studies of protein structures performed at the Shubnikov Institute of Crystallography of the Russian Academy of Sciences from the 1960s up to now.</p>\",\"PeriodicalId\":527,\"journal\":{\"name\":\"Crystallography Reports\",\"volume\":\"69 2\",\"pages\":\"121 - 138\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2024-06-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Crystallography Reports\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1063774524600078\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CRYSTALLOGRAPHY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Crystallography Reports","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1134/S1063774524600078","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CRYSTALLOGRAPHY","Score":null,"Total":0}
引用次数: 0
摘要
摘要 大分子 X 射线晶体学或蛋白质晶体学的发展和形成是 20 世纪最重要的科学成就之一。在原子水平上建立蛋白质和核酸大分子三维结构的可能性确保了分子生物学、生物化学、生物工程和生物技术的快速发展,并使研究人员达到了现代药理学的水平。本综述介绍了俄罗斯科学院舒布尼科夫晶体学研究所从 20 世纪 60 年代至今对蛋白质结构进行研究的成果。
X-ray Structural Studies of Proteins at the Shubnikov Institute of Crystallography of the Russian Academy of Sciences
The development and formation of X-ray crystallography of macromolecules, or protein crystallography, is one of the most important achievements of science in the 20th century. The possibility of establishing the three-dimensional structures of macromolecules of proteins and nucleic acids at atomic level has ensured the rapid development of molecular biology, biochemistry, bioengineering, and biotechnology and allowed researchers to reach the modern level of pharmacology. The review considers the results of studies of protein structures performed at the Shubnikov Institute of Crystallography of the Russian Academy of Sciences from the 1960s up to now.
期刊介绍:
Crystallography Reports is a journal that publishes original articles short communications, and reviews on various aspects of crystallography: diffraction and scattering of X-rays, electrons, and neutrons, determination of crystal structure of inorganic and organic substances, including proteins and other biological substances; UV-VIS and IR spectroscopy; growth, imperfect structure and physical properties of crystals; thin films, liquid crystals, nanomaterials, partially disordered systems, and the methods of studies.