叶绿素抑制芬顿反应引发的脂质过氧化反应

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology

Biophysics Pub Date : 2024-07-04 DOI:10.1134/S0006350924700015

L. A. Romodin

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引用次数: 0

摘要

利用芬顿反应建立了一个系统模型，在该模型中产生了与水的辐射分解过程中形成的微粒相似的微粒。在叶绿素的作用下，通过化学发光法评估了系统中形成的羟自由基对反应的抑制作用。结果表明，叶绿素钠-铜对 Fenton 反应引起的磷脂酸过氧化反应所伴随的化学发光具有剂量依赖性的抑制作用。据此，可以得出结论，叶绿素铜可以抑制脂质放射性毒素的代谢，即脂质过氧化（LP），它是由水的放射性分解产物攻击脂质分子引起的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chlorophyllin Inhibits Lipid Peroxidation Triggered by the Fenton Reaction

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Chlorophyllin Inhibits Lipid Peroxidation Triggered by the Fenton Reaction

Using the Fenton reaction, a system has been modeled in which particles similar to those formed during the radiolysis of water were generated. The suppression of reactions caused by hydroxyl radicals formed in the system under the action of chlorophyllin is evaluated by the chemiluminescence method. It has been shown that sodium-copper chlorophyllin dose-dependently inhibits the chemiluminescence accompanying the phosphatidic acid peroxidation induced by the Fenton reaction. Based on this, it is concluded that copper chlorophyllin can inhibit the metabolism of lipid radiotoxins, lipid peroxidation (LP), caused by the attack of water radiolysis products on lipid molecules.

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.