母体疾病与后代肾脏和泌尿道先天性异常:一项队列研究。

IF 6.1 2区 医学 Q1 PEDIATRICS
Qiang Ma, Ya-Qi Li, Qing-Tang Meng, Bo Yang, Hai-Tao Zhang, Hua Shi, Chang-You Liu, Tian-Chao Xiang, Na Zhao, Jia Rao
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引用次数: 0

摘要

背景:先天性肾脏和泌尿道畸形(CAKUT)是产前诊断为发育畸形的最常见原因。本研究旨在评估母体疾病与后代先天性肾脏和尿路畸形之间的关系:这项回顾性研究登记了一家医疗中心 2020 年 1 月至 2022 年 12 月期间登记的所有孕妇。收集了孕产妇非传染性疾病的医疗信息,包括肥胖、高血压、糖尿病、肾脏疾病、甲状腺功能亢进、甲状腺功能减退、精神疾病、癫痫、癌症和自身免疫性疾病。根据怀孕三个月时的超声波扫描记录,诊断结果分为孤立性尿路扩张(UTD)或肾脏异常。通过多变量逻辑回归建立了预测产前 CAKUT 的模型:结果:在19656名孕妇中,围产期超声检查发现了114个可疑CAKUT胎儿(5.8/1000),其中89例为孤立性UTD,25例为肾脏异常。母亲患有妊娠糖尿病、甲状腺功能障碍、神经精神疾病、贫血、卵巢和子宫疾病的,其胎儿在产前发生 CAKUT 的风险会增加。利用四个混杂因素,即妊娠糖尿病、妊娠高血压、母体甲状腺功能障碍和肝病,建立了一个孤立UTD预测模型。同样,根据四个不同的混杂因素,即母体甲状腺功能障碍、妊娠糖尿病、卵巢/子宫疾病和肾脏疾病,建立了一个单独的肾脏异常预测模型:孤立的UTD和肾脏异常与不同的母体疾病有关。结论:孤立性UTD和肾脏异常与不同的孕产妇疾病有关,这些结果可为妊娠的临床管理提供参考,并强调了各种亚型CAKUT的潜在成因差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Maternal diseases and congenital anomalies of the kidney and urinary tract in offspring: a cohort study.

Maternal diseases and congenital anomalies of the kidney and urinary tract in offspring: a cohort study.

Background: Congenital anomalies of the kidneys and urinary tract (CAKUT) are the most common cause of prenatally diagnosed developmental malformation. This study aimed to assess the relationship between maternal diseases and CAKUT in offspring.

Methods: This retrospective study enrolled all pregnant women registered from January 2020 to December 2022 at one medical center. Medical information on maternal noncommunicable diseases, including obesity, hypertension, diabetes mellitus, kidney disease, hyperthyroidism, hypothyroidism, psychiatric disease, epilepsy, cancer, and autoimmune disease was collected. Based on the records of ultrasound scanning during the third trimester, the diagnosis was classified as isolated urinary tract dilation (UTD) or kidney anomalies. Multivariate logistic regression was performed to establish models to predict antenatal CAKUT.

Results: Among the 19,656 pregnant women, perinatal ultrasound detected suspicious CAKUT in 114 (5.8/1000) fetuses, comprising 89 cases with isolated UTD and 25 cases with kidney anomalies. The risk of antenatal CAKUT was increased in the fetuses of mothers who experienced gestational diabetes, thyroid dysfunction, neuropsychiatric disease, anemia, ovarian and uterine disorders. A prediction model for isolated UTD was developed utilizing four confounding factors, namely gestational diabetes, gestational hypertension, maternal thyroid dysfunction, and hepatic disease. Similarly, a separate prediction model for kidney anomalies was established based on four distinct confounding factors, namely maternal thyroid dysfunction, gestational diabetes, disorders of ovarian/uterine, and kidney disease.

Conclusions: Isolated UTD and kidney anomalies were associated with different maternal diseases. The results may inform the clinical management of pregnancy and highlight potential differences in the genesis of various subtypes of CAKUT.

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来源期刊
World Journal of Pediatrics
World Journal of Pediatrics 医学-小儿科
CiteScore
10.50
自引率
1.10%
发文量
592
审稿时长
2.5 months
期刊介绍: The World Journal of Pediatrics, a monthly publication, is dedicated to disseminating peer-reviewed original papers, reviews, and special reports focusing on clinical practice and research in pediatrics. We welcome contributions from pediatricians worldwide on new developments across all areas of pediatrics, including pediatric surgery, preventive healthcare, pharmacology, stomatology, and biomedicine. The journal also covers basic sciences and experimental work, serving as a comprehensive academic platform for the international exchange of medical findings.
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