通过微生物系统进行可持续生化合成的工程战略。

IF 5.3 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Yoseb Song, Kristala L.J. Prather
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引用次数: 0

摘要

对环境的日益关注和应对气候变化的紧迫性,增加了对开发化石燃料和化学品可持续替代品的需求。拥有固有生物合成能力的微生物系统为实现这一目标提供了一种前景广阔的方法。本综述将讨论如何将系统生物学与合成生物学结合起来,以阐明和操纵微生物表型,从而生产出可替代石油衍生化学品的化学品,并推动绿色生物技术的发展。此外,还讨论了人工智能与代谢工程的结合,以促进生物合成途径的精确和数据驱动设计,同时确定了当前的局限性,并提出了优化生物系统的策略,从而推动化学生物学领域朝着可持续化学品生产的方向发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Strategies in engineering sustainable biochemical synthesis through microbial systems

Growing environmental concerns and the urgency to address climate change have increased demand for the development of sustainable alternatives to fossil-derived fuels and chemicals. Microbial systems, possessing inherent biosynthetic capabilities, present a promising approach for achieving this goal. This review discusses the coupling of systems and synthetic biology to enable the elucidation and manipulation of microbial phenotypes for the production of chemicals that can substitute for petroleum-derived counterparts and contribute to advancing green biotechnology. The integration of artificial intelligence with metabolic engineering to facilitate precise and data-driven design of biosynthetic pathways is also discussed, along with the identification of current limitations and proposition of strategies for optimizing biosystems, thereby propelling the field of chemical biology towards sustainable chemical production.

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来源期刊
CiteScore
8.30
自引率
3.40%
发文量
1601
期刊介绍: ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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