{"title":"设计和开发可编程体外胃肠道模型,以评估巴氏杀菌法对番茄红素纳米粒子生物可及性的影响","authors":"M. Anwar Ul Alam , L. Kassama","doi":"10.1016/j.jfoodeng.2024.112211","DOIUrl":null,"url":null,"abstract":"<div><p>To evaluate potential health impact of engineered nanoparticles, evaluation of digestion effect is necessary. Digestion requires micro-management and sequential execution of complex enzymatic mechanisms with controlled human digestion environment. The objective of this study was to develop an automated <em>in-vitro</em> digestive system to assess bio-accessibility of encapsulated lycopene nanoparticles in model fruit juice. Lycopene was encapsulated in polylactic acid (PLA-LNP) and polylactic co-glycolic acid (PLGA-LNP) and evaluated the bio-accessibility in a programmable <em>in-vitro</em> human digestive system operated with high sensitivity (25–30μs) and volume accuracy (97.37–100%). Pasteurized Model juice containing PLA-LNP, revealing higher bio-accessibility (100%) compared to PLGA-LNP (73%) counterparts. Absorption profile of both types of nanoparticles followed Korsmeyer-Peppas diffusion model at R<sup>2</sup> value of 0.98. All types of nanoparticles with different treatments followed non-Fickian types of diffusion except PLGA-PLA with microwave pasteurization. This automated <em>in-vitro</em> digestive system holds significant potential for advancing drug discovery and delivery studies in the future.</p></div>","PeriodicalId":359,"journal":{"name":"Journal of Food Engineering","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Designing and developing a programmable in vitro gastrointestinal model to assess the impact of pasteurization on the bioaccessibility of lycopene nanoparticles\",\"authors\":\"M. Anwar Ul Alam , L. Kassama\",\"doi\":\"10.1016/j.jfoodeng.2024.112211\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>To evaluate potential health impact of engineered nanoparticles, evaluation of digestion effect is necessary. Digestion requires micro-management and sequential execution of complex enzymatic mechanisms with controlled human digestion environment. The objective of this study was to develop an automated <em>in-vitro</em> digestive system to assess bio-accessibility of encapsulated lycopene nanoparticles in model fruit juice. Lycopene was encapsulated in polylactic acid (PLA-LNP) and polylactic co-glycolic acid (PLGA-LNP) and evaluated the bio-accessibility in a programmable <em>in-vitro</em> human digestive system operated with high sensitivity (25–30μs) and volume accuracy (97.37–100%). Pasteurized Model juice containing PLA-LNP, revealing higher bio-accessibility (100%) compared to PLGA-LNP (73%) counterparts. Absorption profile of both types of nanoparticles followed Korsmeyer-Peppas diffusion model at R<sup>2</sup> value of 0.98. All types of nanoparticles with different treatments followed non-Fickian types of diffusion except PLGA-PLA with microwave pasteurization. This automated <em>in-vitro</em> digestive system holds significant potential for advancing drug discovery and delivery studies in the future.</p></div>\",\"PeriodicalId\":359,\"journal\":{\"name\":\"Journal of Food Engineering\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Food Engineering\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0260877424002772\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Food Engineering","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0260877424002772","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
Designing and developing a programmable in vitro gastrointestinal model to assess the impact of pasteurization on the bioaccessibility of lycopene nanoparticles
To evaluate potential health impact of engineered nanoparticles, evaluation of digestion effect is necessary. Digestion requires micro-management and sequential execution of complex enzymatic mechanisms with controlled human digestion environment. The objective of this study was to develop an automated in-vitro digestive system to assess bio-accessibility of encapsulated lycopene nanoparticles in model fruit juice. Lycopene was encapsulated in polylactic acid (PLA-LNP) and polylactic co-glycolic acid (PLGA-LNP) and evaluated the bio-accessibility in a programmable in-vitro human digestive system operated with high sensitivity (25–30μs) and volume accuracy (97.37–100%). Pasteurized Model juice containing PLA-LNP, revealing higher bio-accessibility (100%) compared to PLGA-LNP (73%) counterparts. Absorption profile of both types of nanoparticles followed Korsmeyer-Peppas diffusion model at R2 value of 0.98. All types of nanoparticles with different treatments followed non-Fickian types of diffusion except PLGA-PLA with microwave pasteurization. This automated in-vitro digestive system holds significant potential for advancing drug discovery and delivery studies in the future.
期刊介绍:
The journal publishes original research and review papers on any subject at the interface between food and engineering, particularly those of relevance to industry, including:
Engineering properties of foods, food physics and physical chemistry; processing, measurement, control, packaging, storage and distribution; engineering aspects of the design and production of novel foods and of food service and catering; design and operation of food processes, plant and equipment; economics of food engineering, including the economics of alternative processes.
Accounts of food engineering achievements are of particular value.