Atiqul Alam Chowdhury , Md Rezaul Hoque Khan , Mohammad Rakibul Islam , A.N.M. Iftekher , Md Sanowar Hosen , Mhamud Hasan Mim , Mirza Muntasir Nishat
{"title":"注入金纳米线的方形覆层 SPR-PCF 生物传感器用于检测各种癌细胞","authors":"Atiqul Alam Chowdhury , Md Rezaul Hoque Khan , Mohammad Rakibul Islam , A.N.M. Iftekher , Md Sanowar Hosen , Mhamud Hasan Mim , Mirza Muntasir Nishat","doi":"10.1016/j.sbsr.2024.100670","DOIUrl":null,"url":null,"abstract":"<div><p>This research work introduces a Surface Plasmon Resonance (SPR) based Photonic Crystal Fiber (PCF) sensor using gold nanowires as plasmonic material designed for the detection of various cancer cells, boasting remarkable sensitivity and ease of fabrication. The sensor's structure was devised and analyzed using the Finite Element Method (FEM) of COMSOL v5.5, with a focus on exploring the impact of varying geometric parameters on its overall performance. The simulation utilized extremely fine mesh elements to ensure the utmost accuracy. Excitation between the core and plasmonic modes is achieved using Gold (Au) nanowires. The determination of the sensor's wavelength sensitivity involves assessing the resonance wavelength shift between samples of normal and cancerous cells. Simultaneously, the measurement of amplitude sensitivity is accomplished through a comparison of the amplitudes associated with their respective confinement losses. Various parameters of the PCF were varied during the experimentation, leading to the achievement of exceptionally high Amplitude Sensitivity (AS) of <span><math><mo>−</mo><mn>273.16</mn></math></span> RIU<sup>−1</sup>, <span><math><mo>−</mo><mn>286.58</mn></math></span> RIU<sup>−1</sup>, <span><math><mo>−</mo><mn>455.59</mn></math></span> RIU<sup>−1</sup>, <span><math><mo>−</mo><mn>698.76</mn></math></span> RIU<sup>−1</sup>, <span><math><mo>−</mo><mn>1172.72</mn></math></span> RIU<sup>−1</sup> and <span><math><mo>−</mo><mn>1971.30</mn></math></span> RIU<sup>−1</sup> for Skin Cancer, Cervical Cancer, Blood Cancer, Adrenal Gland Cancer, Breast Type-1 Cancer and Breast Type-2 Cancer respectively. Additionally, the Wavelength Sensitivity (WS) values were found to be <span><math><mn>6500</mn></math></span> nm/RIU, <span><math><mn>14583.33</mn></math></span> nm/RIU, <span><math><mn>16428.57</mn></math></span> nm/RIU, <span><math><mn>25714.28</mn></math></span> nm/RIU, <span><math><mn>32857.14</mn></math></span> nm/RIU, and <span><math><mn>35714.28</mn></math></span> nm/RIU for the same cancer types, respectively. The achieved resolutions for wavelength sensitivity are <span><math><mn>1.54</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>5</mn></mrow></msup></math></span> RIU, <span><math><mn>6.86</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></math></span> RIU, <span><math><mn>6.09</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></math></span> RIU, <span><math><mn>3.89</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></math></span> RIU, <span><math><mn>3.04</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></math></span> RIU and <span><math><mn>2.80</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></math></span> RIU, while the resolutions for amplitude sensitivity are <span><math><mn>7.32</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>5</mn></mrow></msup></math></span> RIU, <span><math><mn>8.37</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>5</mn></mrow></msup></math></span> RIU, <span><math><mn>3.07</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>5</mn></mrow></msup></math></span> RIU, <span><math><mn>2.00</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>5</mn></mrow></msup></math></span> RIU, <span><math><mn>1.19</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>5</mn></mrow></msup></math></span> RIU and <span><math><mn>7.10</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></math></span> RIU for the respective cancer types mentioned above. The design of the presented biosensor is notably uncomplicated and can be readily manufactured using contemporary fabrication techniques. In summary, the remarkable sensitivity exhibited by the proposed SPR-based PCF (SPR-PCF) biosensor, shows significant potential for enhancing the detection of cancer cells.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":null,"pages":null},"PeriodicalIF":5.4000,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000527/pdfft?md5=89c3e763e14f3584e3105896c5d29337&pid=1-s2.0-S2214180424000527-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Gold nanowire-infused square-clad SPR-PCF biosensor for detection of various cancer cells\",\"authors\":\"Atiqul Alam Chowdhury , Md Rezaul Hoque Khan , Mohammad Rakibul Islam , A.N.M. Iftekher , Md Sanowar Hosen , Mhamud Hasan Mim , Mirza Muntasir Nishat\",\"doi\":\"10.1016/j.sbsr.2024.100670\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This research work introduces a Surface Plasmon Resonance (SPR) based Photonic Crystal Fiber (PCF) sensor using gold nanowires as plasmonic material designed for the detection of various cancer cells, boasting remarkable sensitivity and ease of fabrication. The sensor's structure was devised and analyzed using the Finite Element Method (FEM) of COMSOL v5.5, with a focus on exploring the impact of varying geometric parameters on its overall performance. The simulation utilized extremely fine mesh elements to ensure the utmost accuracy. Excitation between the core and plasmonic modes is achieved using Gold (Au) nanowires. The determination of the sensor's wavelength sensitivity involves assessing the resonance wavelength shift between samples of normal and cancerous cells. Simultaneously, the measurement of amplitude sensitivity is accomplished through a comparison of the amplitudes associated with their respective confinement losses. Various parameters of the PCF were varied during the experimentation, leading to the achievement of exceptionally high Amplitude Sensitivity (AS) of <span><math><mo>−</mo><mn>273.16</mn></math></span> RIU<sup>−1</sup>, <span><math><mo>−</mo><mn>286.58</mn></math></span> RIU<sup>−1</sup>, <span><math><mo>−</mo><mn>455.59</mn></math></span> RIU<sup>−1</sup>, <span><math><mo>−</mo><mn>698.76</mn></math></span> RIU<sup>−1</sup>, <span><math><mo>−</mo><mn>1172.72</mn></math></span> RIU<sup>−1</sup> and <span><math><mo>−</mo><mn>1971.30</mn></math></span> RIU<sup>−1</sup> for Skin Cancer, Cervical Cancer, Blood Cancer, Adrenal Gland Cancer, Breast Type-1 Cancer and Breast Type-2 Cancer respectively. Additionally, the Wavelength Sensitivity (WS) values were found to be <span><math><mn>6500</mn></math></span> nm/RIU, <span><math><mn>14583.33</mn></math></span> nm/RIU, <span><math><mn>16428.57</mn></math></span> nm/RIU, <span><math><mn>25714.28</mn></math></span> nm/RIU, <span><math><mn>32857.14</mn></math></span> nm/RIU, and <span><math><mn>35714.28</mn></math></span> nm/RIU for the same cancer types, respectively. The achieved resolutions for wavelength sensitivity are <span><math><mn>1.54</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>5</mn></mrow></msup></math></span> RIU, <span><math><mn>6.86</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></math></span> RIU, <span><math><mn>6.09</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></math></span> RIU, <span><math><mn>3.89</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></math></span> RIU, <span><math><mn>3.04</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></math></span> RIU and <span><math><mn>2.80</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></math></span> RIU, while the resolutions for amplitude sensitivity are <span><math><mn>7.32</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>5</mn></mrow></msup></math></span> RIU, <span><math><mn>8.37</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>5</mn></mrow></msup></math></span> RIU, <span><math><mn>3.07</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>5</mn></mrow></msup></math></span> RIU, <span><math><mn>2.00</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>5</mn></mrow></msup></math></span> RIU, <span><math><mn>1.19</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>5</mn></mrow></msup></math></span> RIU and <span><math><mn>7.10</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></math></span> RIU for the respective cancer types mentioned above. The design of the presented biosensor is notably uncomplicated and can be readily manufactured using contemporary fabrication techniques. In summary, the remarkable sensitivity exhibited by the proposed SPR-based PCF (SPR-PCF) biosensor, shows significant potential for enhancing the detection of cancer cells.</p></div>\",\"PeriodicalId\":424,\"journal\":{\"name\":\"Sensing and Bio-Sensing Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2024-06-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2214180424000527/pdfft?md5=89c3e763e14f3584e3105896c5d29337&pid=1-s2.0-S2214180424000527-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sensing and Bio-Sensing Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214180424000527\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sensing and Bio-Sensing Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214180424000527","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Gold nanowire-infused square-clad SPR-PCF biosensor for detection of various cancer cells
This research work introduces a Surface Plasmon Resonance (SPR) based Photonic Crystal Fiber (PCF) sensor using gold nanowires as plasmonic material designed for the detection of various cancer cells, boasting remarkable sensitivity and ease of fabrication. The sensor's structure was devised and analyzed using the Finite Element Method (FEM) of COMSOL v5.5, with a focus on exploring the impact of varying geometric parameters on its overall performance. The simulation utilized extremely fine mesh elements to ensure the utmost accuracy. Excitation between the core and plasmonic modes is achieved using Gold (Au) nanowires. The determination of the sensor's wavelength sensitivity involves assessing the resonance wavelength shift between samples of normal and cancerous cells. Simultaneously, the measurement of amplitude sensitivity is accomplished through a comparison of the amplitudes associated with their respective confinement losses. Various parameters of the PCF were varied during the experimentation, leading to the achievement of exceptionally high Amplitude Sensitivity (AS) of RIU−1, RIU−1, RIU−1, RIU−1, RIU−1 and RIU−1 for Skin Cancer, Cervical Cancer, Blood Cancer, Adrenal Gland Cancer, Breast Type-1 Cancer and Breast Type-2 Cancer respectively. Additionally, the Wavelength Sensitivity (WS) values were found to be nm/RIU, nm/RIU, nm/RIU, nm/RIU, nm/RIU, and nm/RIU for the same cancer types, respectively. The achieved resolutions for wavelength sensitivity are RIU, RIU, RIU, RIU, RIU and RIU, while the resolutions for amplitude sensitivity are RIU, RIU, RIU, RIU, RIU and RIU for the respective cancer types mentioned above. The design of the presented biosensor is notably uncomplicated and can be readily manufactured using contemporary fabrication techniques. In summary, the remarkable sensitivity exhibited by the proposed SPR-based PCF (SPR-PCF) biosensor, shows significant potential for enhancing the detection of cancer cells.
期刊介绍:
Sensing and Bio-Sensing Research is an open access journal dedicated to the research, design, development, and application of bio-sensing and sensing technologies. The editors will accept research papers, reviews, field trials, and validation studies that are of significant relevance. These submissions should describe new concepts, enhance understanding of the field, or offer insights into the practical application, manufacturing, and commercialization of bio-sensing and sensing technologies.
The journal covers a wide range of topics, including sensing principles and mechanisms, new materials development for transducers and recognition components, fabrication technology, and various types of sensors such as optical, electrochemical, mass-sensitive, gas, biosensors, and more. It also includes environmental, process control, and biomedical applications, signal processing, chemometrics, optoelectronic, mechanical, thermal, and magnetic sensors, as well as interface electronics. Additionally, it covers sensor systems and applications, µTAS (Micro Total Analysis Systems), development of solid-state devices for transducing physical signals, and analytical devices incorporating biological materials.