老年人脑源性神经营养因子与催产素之间的相关性

Ryuzo Orihashi , Yoshiomi Imamura , Yutaka Kunitake , Yoshito Mizoguchi
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引用次数: 0

摘要

背景以往的一些研究表明,脑源性神经营养因子(BDNF)和催产素与痴呆症、抑郁症和心理健康有关。本研究旨在测量社区老年人的血清 BDNF 和催产素水平,并评估研究队列中这两种生物标志物之间的关系。方法本调查于 2016 年 11 月至 2017 年 9 月期间在日本佐贺县伊万里市黑川町进行,参与者为年龄≥ 65 岁的社区老年人。研究人员采集了他们的血样,利用酶联免疫吸附法测定其血清BDNF和催产素水平。结果 共分析了 95 名参与者(男性 25 人,女性 70 人;平均年龄分别为 78.24 ± 3.85 岁和 77.96 ± 5.52 岁)。分析结果表明,即使调整了年龄、性别和受教育年限,血清 BDNF 水平与血清催产素水平仍呈正相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation between brain-derived neurotrophic factor and oxytocin in older adults

Background

Several previous studies have demonstrated that brain-derived neurotrophic factor (BDNF) and oxytocin are associated with dementia, depression, and mental health. The aim of this study was to measure the serum BDNF and oxytocin levels of community-dwelling older adults and evaluate the relationship between the two biomarkers in the study cohort.

Methods

This survey was conducted between November 2016 and September 2017 in Kurokawa-cho, Imari, Saga Prefecture, Japan, and the participants were community-dwelling older adults aged ≥ 65 years old. Their blood samples were collected for the measurement of their serum BDNF and oxytocin levels using enzyme-linked immunosorbent assays. The relationship between serum BDNF and oxytocin levels was analyzed using correlation and multiple regression analyses.

Results

A total of 95 participants (25 men and 70 women; mean age: 78.24 ± 3.85 years and 77.96 ± 5.52 years, respectively) were analyzed. The results of the analyses indicated that serum BDNF level was positively associated with serum oxytocin level, even after adjusting for age, sex, and years of education.

Conclusion

The results of this study suggest that BDNF and oxytocin may interact in older adults and may be associated with maintaining good mental health among them.

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