治疗 AUD 的新兴 GPCR 靶点：临床前研究的启示

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2024-07-05 DOI:10.1016/j.conb.2024.102896

Roberta Goncalves Anversa , Maiya L. Barron , Leigh C. Walker , Andrew J. Lawrence

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引用次数: 0

摘要

G 蛋白偶联受体（GPCR）是中枢神经系统中最大的一组膜受体，也是细胞间信号转导的关键蛋白之一。目前，市场上有许多药物通过 GPCRs 起作用，这些受体仍然是治疗脑部疾病（包括酒精使用障碍 (AUD)）的诱人靶点。在此，我们将以过去 5 年为重点，介绍有可能减少酒精摄入过量相关行为的 GPCR 靶点的最新文献。具体而言，我们将重点关注具有诱人药理特征的化合物的临床前证据，以及未来用于治疗 AUD 的临床研究的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Emerging GPCR targets for AUD: Insights from preclinical studies

G protein-coupled receptors (GPCRs) are the largest group of membrane receptors in the central nervous system and one of the key proteins for signal transduction between cells. Currently, many drugs available on the market act via GPCRs and these receptors remain attractive targets for the treatment of brain disorders, including alcohol use disorder (AUD). Here, we describe the most recent literature, with a primary focus on the past 5 years, on GPCR targets with the potential for reducing behaviours associated with excessive alcohol intake. Specifically, we focus on preclinical evidence of compounds with attractive pharmacological profiles and potential for future clinical investigation for the treatment of AUD.

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience