Arman Mirzaaghaian, Ming Zhao, Md. Mizanur Rahman, Kejun Dong
{"title":"在真实气溶胶呼吸条件下,对真实人体肺部模型不同区域进行靶向给药的数值模拟","authors":"Arman Mirzaaghaian, Ming Zhao, Md. Mizanur Rahman, Kejun Dong","doi":"10.1016/j.powtec.2024.120039","DOIUrl":null,"url":null,"abstract":"<div><p>In nearly all the previous studies on the particle transport and deposition of aerosols in human lungs, the airflow rate that is inhaled in the lung is assumed to be either constant or sinusoidal function of time, which does not represent the inhalation of aerosols into the lung in reality. This is the first-ever study of the transport and deposition of aerosols in a realistic human lung model employing transient flow rate for realistic aerosol breathing patterns. The measured transient airflow rate is used as the inlet condition in the numerical simulations, and the particles are released immediately when the patient inhales air into the lung, i.e., when the flow velocity starts to increase from zero. We found that the effects of aerosol size on aerosol deposition in different generations of the lung under realistic breathing conditions follow the same trend as those under constant velocity conditions. However, quantitatively, the deposition efficiencies at different parts of the lung model under the two breathing conditions are significantly different from each other. This conclusion signifies the importance of investigating aerosol deposition using realistic breathing conditions. We conducted numerical simulations for aerosol diameters ranging from 1 μm to 10 μm under transient flow conditions. The deposition efficiency in the mouth-throat area increases with aerosol diameter. The deposition efficiency at the trachea increases with increasing aerosol diameter up to 6 μm, and then it remains nearly unchanged. The maximum deposition efficiencies at generations 2 to 5 occur at aerosol diameters between 1 μm and 10 μm. The quantified effect of aerosol size on the deposition efficiency at every generation of the lung provides useful insight for targeted drug delivery.</p></div>","PeriodicalId":407,"journal":{"name":"Powder Technology","volume":null,"pages":null},"PeriodicalIF":4.5000,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Numerical simulation of targeted drug delivery to different regions of realistic human lung model under realistic aerosol breathing condition\",\"authors\":\"Arman Mirzaaghaian, Ming Zhao, Md. Mizanur Rahman, Kejun Dong\",\"doi\":\"10.1016/j.powtec.2024.120039\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In nearly all the previous studies on the particle transport and deposition of aerosols in human lungs, the airflow rate that is inhaled in the lung is assumed to be either constant or sinusoidal function of time, which does not represent the inhalation of aerosols into the lung in reality. This is the first-ever study of the transport and deposition of aerosols in a realistic human lung model employing transient flow rate for realistic aerosol breathing patterns. The measured transient airflow rate is used as the inlet condition in the numerical simulations, and the particles are released immediately when the patient inhales air into the lung, i.e., when the flow velocity starts to increase from zero. We found that the effects of aerosol size on aerosol deposition in different generations of the lung under realistic breathing conditions follow the same trend as those under constant velocity conditions. However, quantitatively, the deposition efficiencies at different parts of the lung model under the two breathing conditions are significantly different from each other. This conclusion signifies the importance of investigating aerosol deposition using realistic breathing conditions. We conducted numerical simulations for aerosol diameters ranging from 1 μm to 10 μm under transient flow conditions. The deposition efficiency in the mouth-throat area increases with aerosol diameter. The deposition efficiency at the trachea increases with increasing aerosol diameter up to 6 μm, and then it remains nearly unchanged. The maximum deposition efficiencies at generations 2 to 5 occur at aerosol diameters between 1 μm and 10 μm. The quantified effect of aerosol size on the deposition efficiency at every generation of the lung provides useful insight for targeted drug delivery.</p></div>\",\"PeriodicalId\":407,\"journal\":{\"name\":\"Powder Technology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2024-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Powder Technology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0032591024006831\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Powder Technology","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0032591024006831","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
Numerical simulation of targeted drug delivery to different regions of realistic human lung model under realistic aerosol breathing condition
In nearly all the previous studies on the particle transport and deposition of aerosols in human lungs, the airflow rate that is inhaled in the lung is assumed to be either constant or sinusoidal function of time, which does not represent the inhalation of aerosols into the lung in reality. This is the first-ever study of the transport and deposition of aerosols in a realistic human lung model employing transient flow rate for realistic aerosol breathing patterns. The measured transient airflow rate is used as the inlet condition in the numerical simulations, and the particles are released immediately when the patient inhales air into the lung, i.e., when the flow velocity starts to increase from zero. We found that the effects of aerosol size on aerosol deposition in different generations of the lung under realistic breathing conditions follow the same trend as those under constant velocity conditions. However, quantitatively, the deposition efficiencies at different parts of the lung model under the two breathing conditions are significantly different from each other. This conclusion signifies the importance of investigating aerosol deposition using realistic breathing conditions. We conducted numerical simulations for aerosol diameters ranging from 1 μm to 10 μm under transient flow conditions. The deposition efficiency in the mouth-throat area increases with aerosol diameter. The deposition efficiency at the trachea increases with increasing aerosol diameter up to 6 μm, and then it remains nearly unchanged. The maximum deposition efficiencies at generations 2 to 5 occur at aerosol diameters between 1 μm and 10 μm. The quantified effect of aerosol size on the deposition efficiency at every generation of the lung provides useful insight for targeted drug delivery.
期刊介绍:
Powder Technology is an International Journal on the Science and Technology of Wet and Dry Particulate Systems. Powder Technology publishes papers on all aspects of the formation of particles and their characterisation and on the study of systems containing particulate solids. No limitation is imposed on the size of the particles, which may range from nanometre scale, as in pigments or aerosols, to that of mined or quarried materials. The following list of topics is not intended to be comprehensive, but rather to indicate typical subjects which fall within the scope of the journal's interests:
Formation and synthesis of particles by precipitation and other methods.
Modification of particles by agglomeration, coating, comminution and attrition.
Characterisation of the size, shape, surface area, pore structure and strength of particles and agglomerates (including the origins and effects of inter particle forces).
Packing, failure, flow and permeability of assemblies of particles.
Particle-particle interactions and suspension rheology.
Handling and processing operations such as slurry flow, fluidization, pneumatic conveying.
Interactions between particles and their environment, including delivery of particulate products to the body.
Applications of particle technology in production of pharmaceuticals, chemicals, foods, pigments, structural, and functional materials and in environmental and energy related matters.
For materials-oriented contributions we are looking for articles revealing the effect of particle/powder characteristics (size, morphology and composition, in that order) on material performance or functionality and, ideally, comparison to any industrial standard.