利用超高磁场核磁共振成像分析听力猫和围产期耳聋猫的皮质厚度差异

Q4 Neuroscience
Stephen G. Gordon , Alessandra Sacco , Stephen G. Lomber
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引用次数: 0

摘要

在听力缺失的情况下,大脑皮层的可塑性使选定的区域能够重新用于处理其余的感觉模式。这种可塑性可以通过多种方式观察到,包括测量听力人群和耳聋人群大脑皮层灰质的厚度差异,以检测区域适应性。在这项研究中,我们使用超高磁场 7T 磁共振成像扫描仪采集了听力猫(38 只)和围产期耳聋猫(31 只)的 T1 加权图像,以确定猫皮层厚度的标准值以及组间厚度不同的区域。与听力组相比,聋猫感觉相关区域的皮层厚度变化最为明显,而特定的非感觉区域则较薄。此外,听觉剥夺后,左半球的灰质更容易受到厚度变化的影响。这些结果表明,耳聋后大脑感觉皮层和非感觉皮层的适应性有不同的驱动因素,并加强了跨模态可塑性的任务保持模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cortical thickness differences between hearing and perinatally deaf cats using ultra-high field MRI

In the absence of hearing, the plastic nature of the cerebral cortex allows select regions to be repurposed to serve the processing of remaining sensory modalities. This plasticity can be observed in many ways, including measuring the thickness differences of cortical gray matter between hearing and deaf populations to detect regional adaptations. In this study, T1-weighted images were acquired for hearing (n = 38) and perinatally-deafened (n = 31) cats using an ultra-high field 7T MRI scanner to identify normative feline cortical thickness, as well as areas of differing thickness between groups. Most significant changes to sensory-related regions demonstrated thicker cortices in the deaf compared to the hearing group, while specific non-sensory regions were found to be thinner. Furthermore, there was a modest lateralized component, finding that the gray matter of the left hemisphere was more susceptible to thickness changes following auditory deprivation. These results suggest distinct factors driving the adaptations in sensory versus non-sensory cortices in the brain following deafness, and reinforces the task-retainment model of crossmodal plasticity.

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来源期刊
Neuroimage. Reports
Neuroimage. Reports Neuroscience (General)
CiteScore
1.90
自引率
0.00%
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审稿时长
87 days
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