Shijian Feng , Ting Han , Yuntian Chen , Qian Zhang , Bohan Liu , Zhaofa Yin , Yushi He , Cai Tang , Pengan Chen , Xinyi Wang , Tao Lin , Zhongli Huang , Yong Xiang , Banghua Liao , Xiaoran Hu
{"title":"利用生物可降解压电聚乳酸/维生素 B2 复合纳米纤维膜的原位电刺激促进肾脏 I/R 损伤修复","authors":"Shijian Feng , Ting Han , Yuntian Chen , Qian Zhang , Bohan Liu , Zhaofa Yin , Yushi He , Cai Tang , Pengan Chen , Xinyi Wang , Tao Lin , Zhongli Huang , Yong Xiang , Banghua Liao , Xiaoran Hu","doi":"10.1016/j.nanoen.2024.109927","DOIUrl":null,"url":null,"abstract":"<div><p>Ischemia/reperfusion (I/R) injury during renal transplantation remains a prevalent challenge. Recent studies proposed protective effects against renal I/R injury using electric fields during organ preservation stage. However, I/R process extends to the post reperfusion stage and traditional electrical stimulation methods face limitations, requiring power sources and electrodes. Hence, there is a need for implantable, biodegradable materials capable of continuously generating electrical stimulation to treat kidney I/R injury over an extended period. In this work, a polylactide/Vitamin B<sub>2</sub> (PLLA/VB<sub>2</sub>) composite nanofibrous membrane was designed. The incorporation of VB<sub>2</sub> into PLLA, coupled with electrospinning, significantly enhanced its piezoelectric performance and flexibility, thereby enabling optimal adherence and efficient <em>in-situ</em> electrical stimulation. Experimental results underscored that PLLA/VB<sub>2</sub> nanofibrous membrane could mitigate tubular injury, facilitate cell regeneration, and alleviate interstitial fibrosis possibly by preserving mitochondrial structure and function. This innovative approach not only pioneers new strategies for addressing I/R related conditions but also offers potential treatments for a range of diseases linked to oxidative stress.</p></div>","PeriodicalId":394,"journal":{"name":"Nano Energy","volume":null,"pages":null},"PeriodicalIF":16.8000,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Promoting renal I/R injury repair by in-situ electric stimulation using biodegradable piezoelectric polylactide/vitamin B2 composite nanofibrous membrane\",\"authors\":\"Shijian Feng , Ting Han , Yuntian Chen , Qian Zhang , Bohan Liu , Zhaofa Yin , Yushi He , Cai Tang , Pengan Chen , Xinyi Wang , Tao Lin , Zhongli Huang , Yong Xiang , Banghua Liao , Xiaoran Hu\",\"doi\":\"10.1016/j.nanoen.2024.109927\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Ischemia/reperfusion (I/R) injury during renal transplantation remains a prevalent challenge. Recent studies proposed protective effects against renal I/R injury using electric fields during organ preservation stage. However, I/R process extends to the post reperfusion stage and traditional electrical stimulation methods face limitations, requiring power sources and electrodes. Hence, there is a need for implantable, biodegradable materials capable of continuously generating electrical stimulation to treat kidney I/R injury over an extended period. In this work, a polylactide/Vitamin B<sub>2</sub> (PLLA/VB<sub>2</sub>) composite nanofibrous membrane was designed. The incorporation of VB<sub>2</sub> into PLLA, coupled with electrospinning, significantly enhanced its piezoelectric performance and flexibility, thereby enabling optimal adherence and efficient <em>in-situ</em> electrical stimulation. Experimental results underscored that PLLA/VB<sub>2</sub> nanofibrous membrane could mitigate tubular injury, facilitate cell regeneration, and alleviate interstitial fibrosis possibly by preserving mitochondrial structure and function. This innovative approach not only pioneers new strategies for addressing I/R related conditions but also offers potential treatments for a range of diseases linked to oxidative stress.</p></div>\",\"PeriodicalId\":394,\"journal\":{\"name\":\"Nano Energy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.8000,\"publicationDate\":\"2024-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano Energy\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S221128552400675X\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Energy","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221128552400675X","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Promoting renal I/R injury repair by in-situ electric stimulation using biodegradable piezoelectric polylactide/vitamin B2 composite nanofibrous membrane
Ischemia/reperfusion (I/R) injury during renal transplantation remains a prevalent challenge. Recent studies proposed protective effects against renal I/R injury using electric fields during organ preservation stage. However, I/R process extends to the post reperfusion stage and traditional electrical stimulation methods face limitations, requiring power sources and electrodes. Hence, there is a need for implantable, biodegradable materials capable of continuously generating electrical stimulation to treat kidney I/R injury over an extended period. In this work, a polylactide/Vitamin B2 (PLLA/VB2) composite nanofibrous membrane was designed. The incorporation of VB2 into PLLA, coupled with electrospinning, significantly enhanced its piezoelectric performance and flexibility, thereby enabling optimal adherence and efficient in-situ electrical stimulation. Experimental results underscored that PLLA/VB2 nanofibrous membrane could mitigate tubular injury, facilitate cell regeneration, and alleviate interstitial fibrosis possibly by preserving mitochondrial structure and function. This innovative approach not only pioneers new strategies for addressing I/R related conditions but also offers potential treatments for a range of diseases linked to oxidative stress.
期刊介绍:
Nano Energy is a multidisciplinary, rapid-publication forum of original peer-reviewed contributions on the science and engineering of nanomaterials and nanodevices used in all forms of energy harvesting, conversion, storage, utilization and policy. Through its mixture of articles, reviews, communications, research news, and information on key developments, Nano Energy provides a comprehensive coverage of this exciting and dynamic field which joins nanoscience and nanotechnology with energy science. The journal is relevant to all those who are interested in nanomaterials solutions to the energy problem.
Nano Energy publishes original experimental and theoretical research on all aspects of energy-related research which utilizes nanomaterials and nanotechnology. Manuscripts of four types are considered: review articles which inform readers of the latest research and advances in energy science; rapid communications which feature exciting research breakthroughs in the field; full-length articles which report comprehensive research developments; and news and opinions which comment on topical issues or express views on the developments in related fields.