2 型糖尿病患者对高碳水化合物膳食和葡萄糖饮料的血浆胰高血糖素反应的性别差异

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2024-07-04 DOI:10.1016/j.diabres.2024.111769

Weikun Huang , Cong Xie , Karen L. Jones , Michael Horowitz , Christopher K. Rayner , Tongzhi Wu

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引用次数: 0

摘要

空腹胰高血糖素浓度升高和/或餐后胰高血糖素抑制减弱是 2 型糖尿病（T2D）的特征，也是导致高血糖的原因之一。这项研究表明，在 2 型糖尿病患者摄入营养负荷后，男性的高胰高血糖素血症比女性更为突出，从而进一步揭示了与 2 型糖尿病病理生理学有关的性别差异。

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Sex differences in the plasma glucagon responses to a high carbohydrate meal and a glucose drink in type 2 diabetes

Elevated fasting glucagon concentrations and/or attenuated postprandial glucagon suppression are characteristics of type 2 diabetes (T2D) and contribute to hyperglycaemia. This study shows that hyperglucagonaemia is more prominent in males than females after a nutrient load in T2D, adding insights into sex differences in relation to the pathophysiology of T2D.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.